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Investigating How Elephants Evolved To Become Resistant to Cancer


One of the expectations is that as you get a really big body, your burden of cancer should increase because things with big bodies have more cells, says Lynch, PhD, assistant professor in the Department of Biological Sciences in the UB College of Arts and Sciences. The fact that this isn t true across species a long-standing paradox in evolutionary medicine and cancer biology indicates that evolution found a way to reduce cancer risk.
In the new study, We explored how elephants and their living and extinct relatives evolved to be cancer-resistant, Lynch says. We have past research looking at TP53, a well-known tumor suppressor. This time, we said, Let s just look at whether the entire elephant genome includes more copies of tumor suppressors than what you d expect. Is the trend general? Or is the trend specific to one gene? We found that it was general: Elephants have lots and lots and lots of extra copies of tumor suppressor genes, and they all contribute probabl ....

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