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Genetic variants that impact protein binding in immune cells can cause autoimmune diseases

Genetic variants that impact protein binding in immune cells can cause autoimmune diseases
Apr 16 2021
Certain genetic variants that cause modified protein binding in immune cells, are also seen in those at high risk of some autoimmune diseases, new research has found.
Scientists from the Wellcome Sanger Institute, Josep Carreras Leukaemia Research Institute in Spain, and the MRC London Institute of Medical Sciences (LMS) found that certain genetic variants, which alter the binding ability of a protein called PU.1 in neutrophils, are also found to be associated with auto immune disease susceptibility.
This new study, published in
Nature Communications (16 April 2021), builds on previous research called BLUEPRINT. BLUEPRINT revealed how variation in blood cells’ characteristics and numbers can affect a person’s risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, coeliac disease and ty ....

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Chủ động tôm bố mẹ đến giống mới VUS Leader 21

Chủ động tôm bố mẹ đến giống mới VUS Leader 21
vnexpress.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from vnexpress.net Daily Mail and Mail on Sunday newspapers.

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Altering a mosquito's gut genes shows promise to curb malaria

Altering a mosquito s gut genes shows promise to curb malaria
Altering a mosquito s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in
eLife.
The study is the latest in a series of steps toward using CRISPR-Cas9 gene-editing technology to make changes in mosquito genes that could reduce their ability to spread malaria. If further studies support this approach, it could provide a new way to reduce illnesses and deaths caused by malaria.
Growing mosquito resistance to pesticides, as well as malaria parasite resistance to antimalarial drugs, has created an urgent need for new ways to fight the disease. Gene drives are being tested as a new approach. They work by creating genetically modified mosquitoes that, when released into the environment, would spread genes that either reduce mosquito populations or make the insects less likely to s ....

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Residents in majority-Black neighborhoods experience higher rates of severe maternal morbidity

Residents in majority-Black neighborhoods experience higher rates of severe maternal morbidity
Residents in majority-Black neighborhoods experience higher rates of severe pregnancy-related health problems than those living in predominantly-white areas, according to a new study of pregnancies at a Philadelphia-based health system, which was led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The findings, published today in
Obstetrics and Gynecology, suggest that neighborhood-level public health interventions may be necessary in order to lower the rates of severe maternal morbidity such as a heart attack, heart failure, eclampsia, or hysterectomy and mortality in the United States. ....

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Non-invasive neuromodulation approaches can prevent invasive surgery in Parkinson's patients

Non-invasive neuromodulation approaches can prevent invasive surgery in Parkinson s patients
From optogenetics to sonogenetics to magnetognetics, scientists around the world are investigating new techniques to treat Parkinson s disease without the need for invasive surgery.
There is still no treatment that can reverse the effects of Parkinson s disease, a condition estimated to affect 10 million people worldwide. As life expectancy increases, the number of people suffering from this disease is set to rise in the future, making the need for effective treatment a priority.
Doctors prescribe oral medication to alleviate the main symptoms and, for a few patients, use deep brain stimulation. The electrodes stimulate the affected areas and relieve the reactions induced by the disease such as tremor or rigidity. ....

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