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Study reveals new routes to potential treatments for chronic inflammatory conditions


Study reveals new routes to potential treatments for chronic inflammatory conditions
Inflammatory lung diseases such as asthma, COPD and, most recently, COVID-19, have proven difficult to treat. Current therapies reduce symptoms and do little to stop such diseases from continuing to damage the lungs. Much research into treating chronic inflammatory diseases has focused on blocking chemicals called cytokines, which trigger cascades of molecular events that fuel damaging inflammation.
Now, scientists at Washington University School of Medicine in St. Louis have found that such cytokines can drive inflammation in more ways than previously understood, perhaps revealing new routes to potential treatments for chronic inflammatory conditions. ....

Michaelj Holtzman , Jennifer Alexander Brett , Emily Henderson , Division Of Pulmonary , Washington University , Washington University School Of Medicine , Washington University School , Critical Care , Herman Seldin Professor , Lung Disease , Inflammatory Disease , ஜெனிபர் அலெக்சாண்டர் ப்ரெட் , எமிலி ஹென்டர்சன் , பிரிவு ஆஃப் நுரையீரல் , வாஷிங்டன் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , முக்கியமான பராமரிப்பு , ஹெர்மன் செல்தின் ப்ரொஃபெஸர் , நுரையீரல் நோய் , அழற்சி நோய் ,

New strategy blocks chronic lung disease in mice


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IMAGE: Shown is a transmission electron microscope image of exosomes purified from fluid from the lungs of a patient with COPD. A new study from Washington University School of Medicine in.
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Credit: Deb Steinberg/WU Center for Cellular Imaging
Inflammatory lung diseases such as asthma, COPD and, most recently, COVID-19, have proven difficult to treat. Current therapies reduce symptoms and do little to stop such diseases from continuing to damage the lungs. Much research into treating chronic inflammatory diseases has focused on blocking chemicals called cytokines, which trigger cascades of molecular events that fuel damaging inflammation.
Now, scientists at Washington University School of Medicine in St. Louis have found that such cytokines can drive inflammation in more ways than previously understood, perhaps revealing new routes to potential treatments for chronic inflammatory conditions. ....

United States , Michaelj Holtzman , Jennifer Alexander Brett , School Of Medicine , Burroughs Wellcome Fund , National Institutes Of Health , Washington University School Of Medicine , Psc Center , Washington University Center , Division Of Pulmonary , Washington University Digestive Diseases Research Core , Washington University , Siteman Center Flow Cytometry Core , Washington University Genome Engineering , Doris Duke Foundation , National Heart , Blood Institute , American Thoracic Society , Washington University School , Critical Care , Herman Seldin Professor , National Institutes , Early Career Investigator Award , Doris Duke , Cellular Imaging , Pulmonary Morphology ,