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Targeted therapies could exploit unique metabolic features of pancreatic cancer cells Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre (PM) Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or addicted to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell. This addiction is vital for the cancer cell s survival, thereby also making it a precise, potential target against the cancer. ....
E-Mail IMAGE: Senior author and Princess Margaret Scientist Dr. Marianne Koritzinsky s research reveals the potential of targeted therapies to exploit unique metabolic features of pancreatic cancer cells. view more Credit: Visual Services, UHN (Toronto, Friday, May 7, 2021) Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre (PM) Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or addicted to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell. ....
For an album that s quite the downer lyrically, Null s 2 for flinching released March 26 is a refreshing piece of DIY rock. The EP employs grittiness that doesn t get lost in itself, maintaining its integrity thanks to quick-changing melodic instrumentals from Val Brown and Chuck Pack and the clear, constant vocals of Emily Parr. Parr s voice is low and plain, a stable slab of sound against backing instruments that shift as a heart rate does when it goes from resting to fight-or-flight. And that suits a work whose themes lie in strife, both inward and outwards; on the opener Air Supply / Weeds, Parr sings tellingly, pleasing you is like breathing underwater. While many of the subsequent tracks on the EP race with rhythm, 404 starts out slow, as Parr sings I m no angel, I dream about killing you. An interruption of tense drums in the middle is a hint at how the song ends, with a grimy cacophony of release, battering drums and a downpour of guitar as Parr continues hop ....
U of T researchers to help form national Coronavirus Variants Rapid Response Network indiaeducationdiary.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from indiaeducationdiary.in Daily Mail and Mail on Sunday newspapers.
Medicine Follow U of T News U of T researchers receive more than $15 million for infrastructure to study brain inflammation, genetics Jennifer Gommerman and Charles Boone are leading two of four research projects at U of T that recently received support from the Canada Foundation for Innovation (photos by Nick Iwanyshyn and courtesy of Boone) The Canada Foundation for Innovation (CFI) has funded two major projects that will bring new research equipment to the University of Toronto’s Temerty Faculty of Medicine and its hospital partners, including a 7-Tesla MRI and imaging mass cytometry that can visualize protein markers in tissue with microscopic detail. ....