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Community Scoop » Heart Foundation Joins Forces With International Research Funding Group To Improve Global Heart Health

Press Release – The Heart Foundation
Leading cardiovascular research funders, including the Heart Foundation, have joined forces in a new partnership to accelerate the prevention, diagnosis and treatment of the worlds biggest killers, heart disease and stroke. The new Global Cardiovascular …
Leading cardiovascular research funders, including the Heart Foundation, have joined forces in a new partnership to accelerate the prevention, diagnosis and treatment of the world’s biggest killers, heart disease and stroke.
The new Global Cardiovascular Research Funders Forum (GCRFF) unites 11 leading independent international organisations to coordinate funding for global clinical trials and promote international research efforts in heart, stroke and circulatory diseases. ....

United Kingdom , New Zealand , United States , New Zealanders , Gerry Devlin , Charmaine Griffiths , Heart Foundation Is New Zealand , Heart Foundation , American Heart Association , German Centre For Cardiovascular Research , Leducq Foundation , National Heart Foundation Of Australia , Stroke Association Of Canada , British Heart Foundation , Dutch Heart Foundation , Danish Heart Foundation , Institute Of Circulatory , Swedish Heart Lung Foundation , Global Cardiovascular Research Funders Forum , Press Release , Global Cardiovascular , Chief Executive , Foundation Medical Director , Aotearoa New , German Centre , Stroke Association ,

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19.

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show ....

Noord Holland , United States , Miltenyi Biotec , U Cytech Biosciences , Melinda Gates Foundation , Dutch Federation Of University Medical Centers , Innovative Medicines Initiative , Amsterdam Cardiovascular Sciences , Agilent Technologies , Dutch Heart Foundation , Netherlands Organization For Health Research , European Union , Graphpad Software , Discovery Workbench Software , European Union Horizon , Proinflammatory Panel , European Commission , Vrije Universiteit Medical Center , Transatlantic Network Grant , Ethical Committee , Netherlands Cardiovascular Research Initiative , Netherlands Heart Foundation , Sanquin Blood Supply Foundation , Royal Netherlands Academy Of Sciences , Chemokine Panel , Biomarker Group ,

Stores to price less healthy food higher for 'unique' research project

Stores to price less healthy food higher for 'unique' research project
dutchnews.nl - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dutchnews.nl Daily Mail and Mail on Sunday newspapers.

Noord Holland , Josine Stuber , Carolien Martens , Dutch Heart Foundation , Supreme Nudge , நூற்த் ஹாலண்ட் , டச்சு இதயம் அடித்தளம் ,

Patients who are overweight or obese at risk of more severe COVID-19

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IMAGE: Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study.
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Credit: i yunmai
Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study.
The research, led by the Murdoch Children s Research Institute (MCRI) and The University of Queensland and published in
Diabetes Care, found obese or overweight patients are at high risk for having worse COVID-19 outcomes. They are also more likely to require oxygen and invasive mechanical ventilation compared to those with a healthy weight. ....

South Australia , United States , South Africa , Davidp Burgner , Graham Colditz , Jessicae Miller , Siroon Bekkering , Danielle Longmore , Edin Mifsud , Yanshan Zhu , David Burgner , Daniellek Longmore , National Health , Monash University , University Of Queensland , University Of Queensland Dr Kirsty Short , Dutch Heart Foundation Dekker , Washington University , Radboud University Medical Center , Doherty Institute , Department Of Health , Group Leader , Melbourne University , University Of Bern , Research Council , Victorian Government Operational Infrastructure Support Program ,

Opportunities to better detect, manage and treat patients with undiagnosed atrial fibrillation

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(Boston) Atrial fibrillation (AF) is associated with a higher risk of complications including ischemic stroke, cognitive decline, heart failure, myocardial infarction and death. AF frequently is undetected until complications such as stroke or heart failure occur.
While the public and clinicians have an intense interest in detecting AF earlier, the most appropriate strategies to detect undiagnosed AF and medical prognosis and therapeutic implications of AF detected by screening are uncertain.
A new report led by Boston University School of Medicine (BUSM) researcher Emelia J. Benjamin, MD, ScM, builds upon a recently conducted National Heart, Lung, and Blood Institute s virtual workshop that focused on identifying key research priorities related to AF screening. ....

United States , Boston University , United Kingdom , Emeliaj Benjamin , Jeffrey Olgin , Stuart Connolly , Van Gelder , Bristol Myers Squibb , Bristol Meyers Squibb , Boehringer Ingelheim , Boston Biomedical Associates , Dutch Heart Foundation , Sanofi Aventis , European Union Horizon , Mcmaster University , Cardiology Research , German Center , Steering Committee Of The Fitbit Heart Study , Apple Inc , National Institute Of Diabetes , American Heart Association , Janssen Inc , Boston University School Of Medicine , British Heart Foundation , Oxford Biomedical Research Centre , Roivant Sciences ,