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"The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plastic" by Ting Xu, Jiao Liu et al.


Abstract
Diabetic encephalopathy, a severe complication of diabetes mellitus, is characterized by neuroinflammation and aberrant synaptogenesis in the hippocampus leading to cognitive decline. Mammalian target of rapamycin (mTOR) is associated with cognition impairment. Nuclear factor-κB (NF-κB) is a transcription factor of proinflammatory cytokines. Although mTOR has been ever implicated in processes occurring in neuroinflammation, the role of this enzyme on NF-κB signaling pathway remains unclear in diabetic encephalopathy. In the present study, we investigated whether mTOR regulates the NF-κB signaling pathway to modulate inflammatory cytokines and synaptic plasticity in hippocampal neurons. In vitro model was constructed in mouse HT-22 hippocampal neuronal cells exposed to high glucose. With the inhibition of mTOR or NF-κB by either chemical inhibitor or short-hairpin RNA (shRNA)-expressing lentivirus-vector, we examined the effects of mTOR/NF-κB signaling on proinfl ....

Diabetic Encephalopathy , F κb , Synaptic Plasticity ,

Meritor: Fiscal Q2 Earnings Snapshot


Meritor: Fiscal Q2 Earnings Snapshot
May 4, 2021
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TROY, Mich. (AP) Meritor Inc. (MTOR) on Tuesday reported fiscal second-quarter profit of $63 million.
On a per-share basis, the Troy, Michigan-based company said it had net income of 86 cents. Earnings, adjusted for one-time gains and costs, came to 68 cents per share.
The supplier of parts for commercial vehicles and heavy equipment posted revenue of $983 million in the period.
Meritor expects full-year earnings in the range of $2.15 to $2.30 per share, with revenue in the range of $3.65 billion to $3.8 billion.
Meritor shares have decreased roughly 3% since the beginning of the year. The stock has climbed 41% in the last 12 months. ....

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