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Research at Advanced Photon Source laid the groundwork for effective COVID-19 vaccines


Research at Advanced Photon Source laid the groundwork for effective COVID-19 vaccines
There is light at the end of the COVID-19 pandemic tunnel. Several vaccines against the SARS-CoV-2 virus that causes COVID-19 are now in clinical trials, with one developed by Pfizer/BioNTech already having been approved for emergency use in the United States. This has been the fastest development and rollout of any vaccine in history, starting with the first gene sequence released in January. (The previous record was held by the mumps vaccine, which took four years.)
But while this may seem like an overnight success story, the speed and effectiveness of these new vaccines can be in part attributed to the decades of research into infectious diseases that preceded the COVID-19 outbreak. Case in point: five of the vaccines, including those developed by Pfizer/BioNTech and Moderna, contain genetic mutations that increase their effectiveness, mutations based upon work dating back more th ....

United States , Barney Graham , Bob Fischetti , Jason Mclellan , Kizzmekia Corbett , Emily Henderson , Peter Kwong , Stephen Streiffer , Nianshuang Wang , Daniel Wrapp , National Institute Of Allergy , Us Department Of Energy , Southeast Regional Collaborative Access Team , Argonne National Laboratory , Structural Biology Center , Regeneron Pharmaceuticals , Vaccine Research Center , National Institutes Of Health , Drug Administration , University Of Georgia , Office Of Science User Facility , University Of Texas At Austin , Proceedings Of The National Academy Sciences , Advanced Photon Source , Science User Facility , National Institute ,

APS plays foundational role in development of COVID-19 vaccines


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IMAGE: Data taken at the APS shows the neutralizing antibody D25 binding to the F protein of the Respiratory Syncytial Virus (RSV). This binding stabilizes the protein in its prefusion form..
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Credit: Jason McLellan
There is light at the end of the COVID-19 pandemic tunnel. Several vaccines against the SARS-CoV-2 virus that causes COVID-19 are now in clinical trials, with one developed by Pfizer/BioNTech already having been approved for emergency use in the United States. This has been the fastest development and rollout of any vaccine in history, starting with the first gene sequence released in January. (The previous record was held by the mumps vaccine, which took four years.) ....

United States , Barney Graham , Bob Fischetti , Jason Mclellan , Kizzmekia Corbett , Peter Kwong , Stephen Streiffer , Nianshuang Wang , Daniel Wrapp , National Institute Of Allergy , Us Department Of Energy , Southeast Regional Collaborative Access Team , Environmental Research , Office Of Science , Argonne National Laboratory , National Virtual Biotechnology Laboratory , Structural Biology Center , Vaccine Research Center , Uchicago Argonne , Regeneron Pharmaceuticals , National Institutes Of Health , Drug Administration , Office Of Science User Facility , University Of Georgia , University Of Texas At Austin , Proceedings Of The National Academy Sciences ,