தரவுத்தளம் கூட்டமைப்பு News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Stay updated with breaking news from தரவுத்தளம் கூட்டமைப்பு. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.

Top News In தரவுத்தளம் கூட்டமைப்பு Today - Breaking & Trending Today

'Obesity Paradox' in Kidney Cancer Continues in Checkpoint Inhibitor Era


email article
Elevated BMI was tied to improved survival in metastatic renal cell carcinoma (RCC) patients treated with immune checkpoint inhibitors, a retrospective study found.
In the analysis of more than 700 metastatic RCC patients who received PD-1/L1 immunotherapies, those with a BMI of 25 or greater had significantly longer overall survival (OS), with 1-year rates of 79% versus 66% for those with a BMI below that cutoff (HR 0.75, 95% CI 0.57-0.97,
P=0.03), Toni Choueiri, MD, of Dana-Farber Cancer Institute in Boston, and colleagues reported.
These findings are consistent with the obesity paradox that was previously seen during the VEGF-targeted therapy era, the group wrote in ....

United States , Dana Farber Cancer Institute , Toni Choueiri , Ian Ingram , International Metastatic , Database Consortium , Medpage Today , Deputy Managing Editor , Clear Cell Carcinoma Of Kidney , Malignant Tumor Of Kidney , Neoplasm Of Kidney , ஒன்றுபட்டது மாநிலங்களில் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , ஈயந் இஂக்ரம் , சர்வதேச மெட்டாஸ்டேடிக் , தரவுத்தளம் கூட்டமைப்பு , துணை நிர்வகித்தல் ஆசிரியர் , தெளிவானது செல் புற்றுநோய் ஆஃப் கிட்நீ , வீரியம் மிக்கது கட்டி ஆஃப் கிட்நீ , உடல் பருமன் ,

ASCO GU 2021: TIVO-3: Tivozanib in Patients with Advanced Renal Cell Carcinoma Who Have Progressed After Treatment with Axitinib


SHARE
ASCO GU 2021: TIVO-3: Tivozanib in Patients with Advanced Renal Cell Carcinoma Who Have Progressed After Treatment with Axitinib
Published 14 February 2021
(UroToday.com) Tivozanib is a potent and highly selective VEGF receptor tyrosine kinase inhibitor in clinical development for renal cell carcinoma (RCC). Axitinib is also a potent and selective VEGF-receptor inhibitor now commonly part of front-line advanced RCC treatment. In the TIVO-3 trial, tivozanib demonstrated significantly greater progression-free survival (PFS) (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.56-0.94) and objective response rate (ORR) (15.2% versus 7.5%, p=0.003) versus sorafenib in the intention to treat population, in the subset of patients treated with two prior VEGFR-tyrosine kinase inhibitors (TKI), and in patients treated with a prior VEGFR-TKI and an anti-PD-1 antibody. ....

United States , Zachary Klaassen , Brian Rini , Briani Rini , Vanderbilt Ingram Cancer Center , American Society Of Clinical Oncology , Georgia Cancer Center , Augusta University Medical College Of Georgia , Database Consortium , Clinical Oncology , Cancers Symposium , Urologic Oncologist , Assistant Professor , Medical College , Clinical Oncology Genitourinary Cancers Symposium , ஒன்றுபட்டது மாநிலங்களில் , சக்கரி க்லாஸ்சேங் , பிரையன் ரினி , பிரியாணி ரினி , வாண்டர்பில்ட் இஂக்ரம் புற்றுநோய் மையம் , அமெரிக்கன் சமூகம் ஆஃப் மருத்துவ புற்றுநோயியல் , ஜார்ஜியா புற்றுநோய் மையம் , அகஸ்டா பல்கலைக்கழகம் மருத்துவ கல்லூரி ஆஃப் ஜார்ஜியா , தரவுத்தளம் கூட்டமைப்பு , மருத்துவ புற்றுநோயியல் , புற்றுநோய்கள் சிம்போசியம் ,

Exelixis Announces Positive Findings at ASCO GU for CABOMETYX® (cabozantinib) in Patients with Brain Metastases from Renal Cell Carcinoma


Press release content from Business Wire. The AP news staff was not involved in its creation.
Exelixis Announces Positive Findings at ASCO GU for CABOMETYX® (cabozantinib) in Patients with Brain Metastases from Renal Cell Carcinoma
February 8, 2021 GMT
ALAMEDA, Calif. (BUSINESS WIRE) Feb 8, 2021
Exelixis, Inc. (NASDAQ: EXEL) today announced results from a retrospective analysis evaluating CABOMETYX ® (cabozantinib) activity in brain metastases in patients with renal cell carcinoma (RCC). The findings will be presented as part of the Poster Session: Renal Cell Cancer at the 2021 American Society of Clinical Oncology’s Genitourinary Cancers Symposium (ASCO GU), which is being held virtually, February 11-13, 2021. All posters will be available on demand beginning at 5:00 a.m. PT on Thursday, February 11. ....

United States , Toni Choueiri , Susan Hubbard , Lindsay Treadway , Gisela Schwab , International Metastatic , Takeda Pharmaceutical Company , Database Consortium , Exchange Commission , Genitourinary Oncology At Dana Farber Cancer Institute , Lank Center , Product Development , Exelixis Inc , Public Affairs , European Union , Dana Farber Cancer Institute , American Cancer Society , Poster Session , Renal Cell Cancer , Clinical Oncology , Genitourinary Cancers Symposium , Genitourinary Oncology , Nancy Kohlberg Professor , Harvard Medical , Medical Affairs , Chief Medical Officer ,