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SLAS Discovery's July special edition 'Drug discovery targeting COVID-19' now available

SLAS Discovery's July special edition 'Drug discovery targeting COVID-19' now available
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , Lesley Anne Pearson , Euanaf Fordyce , Alain Pierre Petit , Davidw Gray , Robertm Campbell , Edward Kai Hua Chow , School Of Life Sciences , Society For Laboratory Automation , Life Sciences Innovation , National University Of Singapore , Technology For Electrophysical Screening , University Of Dundee , Oak Brook , Special Edition , High Throughput Screening Assay , Identify Inhibitors , Methyltransferase Using Rapidfire Mass , Drug Discovery Unit , Life Sciences , Novel Label Free , Solid Supported Membrane Based Technology , Electrophysical Screening , Modulating Compounds , Transport Activity ,

SLAS Technology June special issue on 3D cell culture

The June edition of SLAS Technology is a Special Issue entitled, Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine. Free online access to the articles in this collection is courtesy of Corning Life Sciences, the issue s sponsor. ....

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SLAS Discovery's June issue on synthetic biology available now

The June edition of SLAS Discovery features the cover article, A Perspective on Synthetic Biology in Drug Discovery and Development Current Impact and Future Opportunities by Florian David, Ph.D. (Chalmers University of Technology, Gothenburg, Sweden), Andrew M. Davis, Ph.D. (AstraZeneca, Cambridge, England, UK). Michael Gossing, Ph.D., Martin A. Hayes, Ph.D., and Elvira Romero, Ph.D., and Louis H. Scott, Ph.D. (AstraZeneca, Gothenburg, Sweden), and Mark J. Wigglesworth, Ph.D. (AstraZeneca, London, England, UK). ....

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SLAS Technology April issue dives into reactive oxygen species

Oak Brook, IL - The April edition of
SLAS Technology features the cover article Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances by Valeria Graceffa, Ph.D. (Institute of Technology Sligo, Sligo, Ireland).
The cover article explores the therapeutic potential of reactive oxygen species (ROS) including applications ranging from wound healing and hair growth enhancement, to cancer treatment, stem cell differentiation and tissue engineering. At low concentrations, ROS can be utilized as inexpensive and convenient inducers of tissue regeneration, triggering stem cell differentiation and enhancing collagen synthesis. Recent cancer studies have represented ROS as the Achilles Heels of cancers given their high basal levels, leaving tumoral cells unable to sufficiently handle the additional source of oxidative stress. Because of this, higher doses of ROS are used for targeted killing of tumor cells. Lack of understanding of the technicalit ....

United States , Robertm Campbell , Valeria Graceffa , Edward Kai Hua Chow , Automated Laboratory , Society For Laboratory Automation , Life Sciences Innovation , National University Of Singapore , Phd Institute Of Technology Sligo , Oak Brook , Reactive Oxygen Species , Technology Sligo , Achilles Heel , Versatile Cloud Based Automation Solution , Remote Design , Experiment Protocols , Pediatric Crohn , Disease Patients , Quiescent Disease Treated , Partial Enteral Nutrition , Feasibility Study , Full Scan Mass Spectrometry Analysis , High Throughput Compound Plate Quality Control , Emerging Fluorescence Based Technique , Protein Profiling , Extracellular Vesicles ,

SLAS Discovery special issue

Oak Brook, IL - The April edition of
SLAS Discovery is a special issue on advances in protein degradation curated by guest editors M. Paola Castaldi, Ph.D., and Stewart L. Fisher, Ph.D.
Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not often delivering the successful results that comes from whole-protein depletion. The pharmacology of PROTACs present challenges, however, namely for the development of orally bioavailable drugs. In the article Target Validation Using PROTACs: Applying the Four Pillars Framework authors Rados?aw P. Nowak, Ph.D., and Lyn H. Jones, Ph.D., describe the application of a translational pharmacology framework (the four pillars) to expedite PROTAC development by informing pharmacokinetic-pharmacodynamic (PKPD) understanding and helping clarify structure-activity relationships. Nowak and Jones hope that the four pillars will serve as a useful guidel ....

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