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Multiple immune reactions when transplanting cartilage into monkeys


Kyoto University
The Noriyuki Tsumaki lab reports the effects of gene editing monkey iPS cells on regenerative medicine for damaged knee cartilage.
Immune rejection is one of the biggest obstacles to a cell therapy. To solve this problem, researchers have been investigating iPS cells that have been gene edited so that they can evade the immune system. While this concept is theoretically possible, there is limited evidence that it works in species resembling humans.
A new study by the laboratory of CiRA Professor Noriyuki Tsumaki shows that this strategy is more complicated than expected when using monkey iPS cells to treat damaged knee cartilage in monkeys. The study can be read in Tissue Engineering Part A. ....

Yuki Okutani , Noriyuki Tsumaki , Akihiro Yamashita , Kengo Abe , Shuichi Matsuda , Miho Morioka , School Of Medicine , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Orhopaedic Surgery , Tissue Engineering Part , Clinical Application , Orhopaedic Surgery , Graduate School , பள்ளி ஆஃப் மருந்து , ப்ச் செல் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ விண்ணப்பம் , கியோட்டோ பல்கலைக்கழகம் , திசு பொறியியல் பகுதி , மருத்துவ விண்ணப்பம் , பட்டதாரி பள்ளி ,