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Osaka City University

Osaka City University
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Shinya Yamanaka , Tetsuo Arakawa , Yoichiro Nambu , Hajime Seki , Ps Cell Research , Kyoto University , Osaka City University , Distinguished Professor Yoichiro Nambu , Nobel Prize , Osaka City , ப்ச் செல் ஆராய்ச்சி , கியோட்டோ பல்கலைக்கழகம் , ஒசகக நகரம் பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , ஒசகக நகரம் ,

Predicting drug absorption in miniatured human liver

Kyoto University
The Kazuo Takayama lab reports that PDMS-based liver-on-chip naturally absorb some drugs, which affects drug toxicity results.
Liver-on-a-chip are miniaturized devices that capture the physiological and mechanical properties of the liver. They are commonly used by researchers to study how the liver metabolizes different compounds and drugs. In a new study seen in ACS Biomaterials Science & Engineering, CiRA Junior Associate Professor Kazuo Takayama and colleagues report which drugs based on their physicochemical properties are most suitable when using liver-on-a-chip to study drug toxicity.
One of the most important tests for any drug approval is hepatotoxicity. In fact, the United States Food and Drug Administration claims it is the number one cause of safety-related drug withdrawal from the market. Thus, exhaustive testing is mandatory, as otherwise a company that has invested billions of dollars on a drug could see it all lost because of ....

United States , Emi Sano , Fumiyoshi Yamashita , Ryosuke Negoro , Hiroyuki Mizuguchi , Kazuo Takayama , Kaori Osugi , Ayaka Sakamoto , Natsumi Mimura , Kazuya Maeda , Sayaka Deguchi , Masahiro Tsuda , Hiroyuki Kusuhara , Ritsumeikan University , Laboratory Of Molecular Pharmacokinetics , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Drug Delivery Research , Drug Administration , School Of Pharmaceutical Sciences , Department Of Micro Engineering , Laboratory Of Biochemistry , College Of Pharmaceutical Sciences Department , Osaka University , Department Of Applied Pharmaceuticals ,

Multiple immune reactions when transplanting cartilage into monkeys

Kyoto University
The Noriyuki Tsumaki lab reports the effects of gene editing monkey iPS cells on regenerative medicine for damaged knee cartilage.
Immune rejection is one of the biggest obstacles to a cell therapy. To solve this problem, researchers have been investigating iPS cells that have been gene edited so that they can evade the immune system. While this concept is theoretically possible, there is limited evidence that it works in species resembling humans.
A new study by the laboratory of CiRA Professor Noriyuki Tsumaki shows that this strategy is more complicated than expected when using monkey iPS cells to treat damaged knee cartilage in monkeys. The study can be read in Tissue Engineering Part A. ....

Yuki Okutani , Noriyuki Tsumaki , Akihiro Yamashita , Kengo Abe , Shuichi Matsuda , Miho Morioka , School Of Medicine , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Orhopaedic Surgery , Tissue Engineering Part , Clinical Application , Orhopaedic Surgery , Graduate School , பள்ளி ஆஃப் மருந்து , ப்ச் செல் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ விண்ணப்பம் , கியோட்டோ பல்கலைக்கழகம் , திசு பொறியியல் பகுதி , மருத்துவ விண்ணப்பம் , பட்டதாரி பள்ளி ,

Developing cancer therapies with stem cells

Developing cancer therapies with stem cells
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Yutaka Yasui , Yohei Kawai , Tomoko Ishii , Kazutaka Obama , Takeshi Ito , Kenji Kawada , Yoshiharu Sakai , Shoichi Iriguchi , Atsutaka Minagawa , Hiroyuki Miyoshi , Shin Kaneko , Co Ltd , School Of Medicine , Shin Kaneko Laboratory , Ps Cell Research , Kyoto University , Department Of Cell Growth , Department Of Surgery , Institute For Advancement Of Clinical , Communications Biology , Cell Growth , Graduate School , Translational Science , Red Cross Hospital , தகேஷி இதோ , தாடை காநெக்கோ ,

Are genetic differences the primary reason for susceptibility and severity of COVID-19?

Are genetic differences the primary reason for susceptibility and severity of COVID-19?
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Kazuo Takayama , Ps Cell Research , Kyoto University , காஸூவொ தக்காயமா , ப்ச் செல் ஆராய்ச்சி , கியோட்டோ பல்கலைக்கழகம் ,