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Predicting drug absorption in miniatured human liver

Kyoto University
The Kazuo Takayama lab reports that PDMS-based liver-on-chip naturally absorb some drugs, which affects drug toxicity results.
Liver-on-a-chip are miniaturized devices that capture the physiological and mechanical properties of the liver. They are commonly used by researchers to study how the liver metabolizes different compounds and drugs. In a new study seen in ACS Biomaterials Science & Engineering, CiRA Junior Associate Professor Kazuo Takayama and colleagues report which drugs based on their physicochemical properties are most suitable when using liver-on-a-chip to study drug toxicity.
One of the most important tests for any drug approval is hepatotoxicity. In fact, the United States Food and Drug Administration claims it is the number one cause of safety-related drug withdrawal from the market. Thus, exhaustive testing is mandatory, as otherwise a company that has invested billions of dollars on a drug could see it all lost because of ....

United States , Emi Sano , Fumiyoshi Yamashita , Ryosuke Negoro , Hiroyuki Mizuguchi , Kazuo Takayama , Kaori Osugi , Ayaka Sakamoto , Natsumi Mimura , Kazuya Maeda , Sayaka Deguchi , Masahiro Tsuda , Hiroyuki Kusuhara , Ritsumeikan University , Laboratory Of Molecular Pharmacokinetics , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Drug Delivery Research , Drug Administration , School Of Pharmaceutical Sciences , Department Of Micro Engineering , Laboratory Of Biochemistry , College Of Pharmaceutical Sciences Department , Osaka University , Department Of Applied Pharmaceuticals ,

Multiple immune reactions when transplanting cartilage into monkeys

Kyoto University
The Noriyuki Tsumaki lab reports the effects of gene editing monkey iPS cells on regenerative medicine for damaged knee cartilage.
Immune rejection is one of the biggest obstacles to a cell therapy. To solve this problem, researchers have been investigating iPS cells that have been gene edited so that they can evade the immune system. While this concept is theoretically possible, there is limited evidence that it works in species resembling humans.
A new study by the laboratory of CiRA Professor Noriyuki Tsumaki shows that this strategy is more complicated than expected when using monkey iPS cells to treat damaged knee cartilage in monkeys. The study can be read in Tissue Engineering Part A. ....

Yuki Okutani , Noriyuki Tsumaki , Akihiro Yamashita , Kengo Abe , Shuichi Matsuda , Miho Morioka , School Of Medicine , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Orhopaedic Surgery , Tissue Engineering Part , Clinical Application , Orhopaedic Surgery , Graduate School , பள்ளி ஆஃப் மருந்து , ப்ச் செல் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ விண்ணப்பம் , கியோட்டோ பல்கலைக்கழகம் , திசு பொறியியல் பகுதி , மருத்துவ விண்ணப்பம் , பட்டதாரி பள்ளி ,

Treating orphan diseases in children

Treating orphan diseases in children
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Japan General , Naotomo Kambe , Megumuk Saito , Megumu Saito , Yohko Kitagawa , Yuichi Yamasaki , Ps Cell Research , Department Of Clinical Application , Kyoto University , Kansai Medical University , Takeda Pharmaceutical Company , Kagoshima University , Kyoto University Graduate School Of Medicine , Department Of Pediatrics , Department Of Dermatology , Clinical Application , Takeda Pharmaceutical Company Limited , Kyoto University Graduate School , ஜப்பான் ஜநரல் , ப்ச் செல் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ விண்ணப்பம் , கியோட்டோ பல்கலைக்கழகம் , கன்சாய் மருத்துவ பல்கலைக்கழகம் , டாகேடா மருந்து நிறுவனம் , ககோஷிமா பல்கலைக்கழகம் , கியோட்டோ பல்கலைக்கழகம் பட்டதாரி பள்ளி ஆஃப் மருந்து ,

Enhanced muscle regeneration using stem cells

Kyoto University
The Hidetoshi Sakurai laboratory reports two new markers that should advance iPS cell therapies for muscle degeneration.
Muscular dystrophy describes a group of muscle degenerative congenital diseases. The severity and rates differ between disease and patient, but in all cases the degeneration progresses, sometimes leaving patients in wheelchairs and unable to breathe without artificial respiration. With no present cure, scientists are experimenting with the transplantation of muscle progenitor cells, but the amounts needed can only be made from stem cells such as iPS cells. A new study by CiRA Associate Professor Hidetoshi Sakurai and colleagues report two cell surface receptors, CDH13 and FGFR4, that are expected to advance iPS cell therapies for these diseases. ....

Mingming Zhao , Akitsu Hotta , Naoshi Sugimoto , Antonio Lucena Cacace , Tatsuya Jonouchi , Hidetoshi Sakurai , Takuma Mizusawa , Mitsuru Sasaki Honda , Minas Nalbandian , Masahiko Yasuda , Yoshinori Yoshida , Department Of Clinical Application , Kyoto University , Central Institute For Experimental Animals , Department Of Cell Growth , Professor Hidetoshi Sakurai , Stem Cell , Myogenic Cell Purification Toward , Clinical Application , Cell Growth , Experimental Animals , அன்டோனியோ ழூசெனா காஸாஸ் , துறை ஆஃப் மருத்துவ விண்ணப்பம் , கியோட்டோ பல்கலைக்கழகம் , மைய நிறுவனம் க்கு சோதனை விலங்குகள் , துறை ஆஃப் செல் வளர்ச்சி ,

A simple step to enhance CRISPR-Cas9 genome editing

Kyoto University
The Hotta lab shows that protection from cellular RNA enhances the genome editing of iPS cells.
The ability for scientists to edit human genomic DNA has been around for decades. Such research has revealed how a single mutation in just one of the billions of base pairs in the human genome can cause destructive diseases. In the past decade, advances in CRISPR-Cas9 technology have taken DNA editing a major step farther and promise to revolutionize regenerative medicine. One of the biggest challenges for therapeutic application is the efficiency of precise genome editing. A new study by Junior Associate Professor Akitsu Hotta and colleagues reports a simple but key step in the delivery of CRISPR-Cas9 into iPS cells that enhances this efficiency. ....

Takahiro Iguchi , Peter Gee , Miyuki Ono , Akitsu Hotta , Yuto Kita , Huaigeng Xu , Xiouh Wang , Noriko Sasakawa , Akihiro Kagita , Ps Cell Research , Department Of Clinical Application , Cira Foundation , Kyoto University , Junior Associate Professor Akitsu Hotta , Mandy Lung , Stem Cell , Clinical Application , Regenerative Medicine , பீட்டர் ஜீ , மியூகி ஓனோ , ப்ச் செல் ஆராய்ச்சி , துறை ஆஃப் மருத்துவ விண்ணப்பம் , சிரா அடித்தளம் , கியோட்டோ பல்கலைக்கழகம் , மண்டி நுரையீரல் , தண்டு செல் ,