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Irish study pinpoints new therapeutic target for atopic dermatitis

Irish study pinpoints new therapeutic target for atopic dermatitis
A key mechanism underlying bacterial skin colonisation in atopic dermatitis (AD) has been discovered by Irish researchers.
AD, commonly known as eczema is the most common chronic inflammatory skin disorder in children, affecting millions around the globe and 15 to 20 per cent of people in childhood.
During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.
The bacterium
Staphylococcus aureus (
S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. By studying the attachment of the bacterium to “corneocytes”, which are dead, flattened skin cells in the outer layer of the skin, researchers at the School of Genetics and Microbiology and School of Clinical Medicine, Trinity College Dublin (TCD), investigated the human and bacterial factors that enabled S. aureus to interact with s ....

United States , Alan Irvine , Joan Geoghegan , School Of Genetics , School Of Clinical Medicine , Trinity Department Of Microbiology , Trinity College Dublin , Clinical Medicine , National Academy , Associate Professor , ஒன்றுபட்டது மாநிலங்களில் , ஆலன் இவைந் , ஜோன் ஜியோகேகன் , பள்ளி ஆஃப் ஜெநெடிக்ஸ் , பள்ளி ஆஃப் மருத்துவ மருந்து , திரித்துவம் துறை ஆஃப் நுண்ணுயிரியல் , திரித்துவம் கல்லூரி டப்ளின் , மருத்துவ மருந்து , தேசிய கலைக்கழகம் , இணை ப்ரொஃபெஸர் ,

Violet robot deployed in midlands hospital to help wipe out Covid-19

The roboticis team at Trinity College Dublin have developed a robot they call Violet to help tackle Covid-19 at Portlaoise hospital s sister facility. ....

Michael Beckett , Conor Mcginn , Trinity Department Of Microbiology , Trinity College Dublin , Trinity School Of Engineering , Midland Regional Hospital Tullamore , Covid 19 , Free Articles , Tullamore Hospital , மைக்கேல் பெக்கெட் , கோனார் மகிந் , திரித்துவம் துறை ஆஃப் நுண்ணுயிரியல் , திரித்துவம் கல்லூரி டப்ளின் , திரித்துவம் பள்ளி ஆஃப் பொறியியல் , மிட்லாண்ட் பிராந்திய மருத்துவமனை துல்லமோர் , இலவசம் கட்டுரைகள் , துல்லமோர் மருத்துவமனை ,

Trinity researchers discover key mechanism underlying bacterial skin colonization in atopic dermatitis

Trinity researchers discover key mechanism underlying bacterial skin colonization in atopic dermatitis
Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonization in atopic dermatitis, which affects millions around the globe.
Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.
The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate to severe AD, it is vital that we understand how S. aureus colonises AD skin so that we can develop new treatments that directly target the bacterium. ....

United Kingdom , Noord Holland , Alan Irvine , Aisling Towell , Joan Geoghegan , Emily Henderson , National Children Research Centre , University Of Amsterdam , Trinity College Dublin , Irish Research Council , British Skin Foundation , Trinity Department Of Microbiology , School Of Clinical Medicine , Trinity School Of Genetics , Clinical Medicine , National Academy , United States , Associate Professor , Trinity College , Catholique De Louvain , National Children , Research Centre , Atopic Dermatitis , Skin Infection , Staphylococcus Aureus , ஒன்றுபட்டது கிஂக்டம் ,

Discovery pinpoints new therapeutic target for atopic dermatitis

Credit: Dave Cullen
Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe.
Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.
The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate to severe AD, it is vital that we understand how S. aureus colonises AD skin so that we can develop new treatments that directly target the bacterium. ....

United Kingdom , Noord Holland , Alan Irvine , Aisling Towell , Joan Geoghegan , National Children Research Centre , University Of Amsterdam , Trinity College Dublin , Irish Research Council , British Skin Foundation , Trinity Department Of Microbiology , School Of Clinical Medicine , Trinity School Of Genetics , Clinical Medicine , National Academy , United States , Associate Professor , Catholique De Louvain , National Children , Research Centre , Medicine Health , Immunology Allergies Asthma , Pharmaceutical Science , ஒன்றுபட்டது கிஂக்டம் , நூற்த் ஹாலண்ட் , ஆலன் இவைந் ,