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Combining Freeze Drying and High Pressure Homogenisation for Ultra-Fine Nanocrystal Production


Feb 15 2021 Read 275 Times
In recent years, nanomedicine has proven to be key in overcoming many of the challenges associated with poorly water-soluble drugs. Decreasing the size of drug particles can increase bioavailability and solubility, as a result of the increased API surface area.
Due to increased bioavailability, a lower amount of API is required, which in turn leads to a more cost-efficient product, with less risks and side effects for the patient [1].
High pressure homogenisation has long been the favoured method of particle size reduction and is often considered as a first-generation approach. Recently, second-generation approaches have been introduced and these involve a combination of technologies (SmartCrystal processes). One of which is known as the H96 process -the combination of freeze drying, followed by high pressure homogenisation. ....

United Kingdom , Bulletin Of Pharmaceutical Research , Technical Service Team , Biopharma Group , Technical Service , ஒன்றுபட்டது கிஂக்டம் , புல்லட்டின் ஆஃப் மருந்து ஆராய்ச்சி , தொழில்நுட்ப சேவை அணி , தொழில்நுட்ப சேவை ,

Proper fit of face masks is more important than material, study suggests


Date Time
Proper fit of face masks is more important than material, study suggests
A team of researchers studying the effectiveness of different types of face masks has found that in order to provide the best protection against COVID-19, the fit of a mask is as important, or more important, than the material it is made of.
Fitting the face perfectly is a difficult technical challenge and small differences, such as a centimetre wider nose or slightly fuller cheeks, can make or break the fit of a mask
Eugenia O’Kelly
The researchers, from the University of Cambridge, carried out a series of different fit tests, and found that when a high-performance mask – such as an N95, KN95 or FFP2 mask – is not properly fitted, it performs no better than a cloth mask. Minor differences in facial features, such as the amount of fat under the skin, make significant differences in how well a mask fits. ....

United Kingdom , Eugenia Okelly , University Of Cambridge , Cambridge Department Of Engineering , Eugeniao Kelly , Frontline Workers , Public Health , Face Masks , Health Care , Covid 19 , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , கேம்பிரிட்ஜ் துறை ஆஃப் பொறியியல் , முன்னணி தொழிலாளர்கள் , பொது ஆரோக்கியம் , முகம் முகமூடிகள் , ஆரோக்கியம் பராமரிப்பு , சர்வதேச பரவல் ,