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Alterations in the 3D genome structure and effects on fertility revealed

Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB.
The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression.
A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility.
The research, published in
Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm ....

Comunidad Autonoma De Cataluna , Covadonga Vara , Aurora Ruiz Herrera , Nature Communications , Department Of Cellular Biology , National Centre For Genomic Analysis , Centre For Genomic Regulation , Institute Of Biotechnology , Cornell University United States , Department Of Animal Biology , Universitat Aut , Associated Professor , Cellular Biology , Animal Biology , Plant Biology , National Centre , Genomic Analysis , Genomic Regulation , Sequentia Biotech , Cornell University , United States , Cell Biology , Developmental Reproductive Biology , காமுனிடட தன்னாட்சி டி கடலுள் , அரோரா ர்டீஸ் ஹெர்ரெரா , இயற்கை தகவல்தொடர்புகள் ,

Alterations in 3D genome structure and effects on fertility revealed

Alterations in 3D genome structure and effects on fertility revealed
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

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NASA grant enables scientist to explore ways to keep astronauts' bones strong in space

Credit: Kim Ratliff, Augusta University
AUGUSTA, Ga. (Feb.18, 2021) - Extended time in space weakens astronauts bones, so scientists are working to better understand how bone senses and responds to the usual forces placed upon it with the goal of keeping their bones strong.
The skeleton s ability to adapt to mechanical loading the forces put on bone by both gravity and muscle in response to movement is critical to bone health, and circumstances like spaceflight or a spinal cord injury can interfere, says Dr. Meghan E. McGee-Lawrence, biomedical engineer in the Department of Cellular Biology and Anatomy at the Medical College of Georgia. ....

United States , Paul Mcneil , Meghane Mcgee Lawrence , Department Of Cellular Biology , College Of Georgia , Bone Diseases National Resource Center , National Institutes Of Health , Cellular Biology , Medical College , International Space Station , Related Bone Diseases National Resource Center , National Institutes , Cell Biology , Medicine Health , Orthopedic Medicine , Space Planetary Science , ஒன்றுபட்டது மாநிலங்களில் , பால் மக்நீல் , துறை ஆஃப் செல்லுலார் உயிரியல் , கல்லூரி ஆஃப் ஜார்ஜியா , எலும்பு நோய்கள் தேசிய வள மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , செல்லுலார் உயிரியல் , மருத்துவ கல்லூரி , சர்வதேச இடம் நிலையம் , தொடர்புடையது எலும்பு நோய்கள் தேசிய வள மையம் ,

Biomedical engineer receives NASA grant to find ways to keep astronauts' bones strong in space

Extended time in space weakens astronauts' bones, so scientists are working to better understand how bone senses and responds to the usual forces placed upon it with the goal of keeping their bones strong. ....

United States , Paul Mcneil , Meghane Mcgee Lawrence , Emily Henderson , Department Of Cellular Biology , College Of Georgia , Cellular Biology , Medical College , International Space Station , Bone Health , Cell Membrane , Physical Activity , Spinal Cord Injury , ஒன்றுபட்டது மாநிலங்களில் , பால் மக்நீல் , எமிலி ஹென்டர்சன் , துறை ஆஃப் செல்லுலார் உயிரியல் , கல்லூரி ஆஃப் ஜார்ஜியா , செல்லுலார் உயிரியல் , மருத்துவ கல்லூரி , சர்வதேச இடம் நிலையம் , எலும்பு ஆரோக்கியம் , செல் சவ்வு , உடல் நடவடிக்கை , முதுகெலும்பு தண்டு காயம் ,

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing
SARS-CoV-2 genome is three times larger than influenza genome. Both consist of NRA molecules that mutate when replicate. It is essential to know its mutant spectrum, in other words, its fingerprints , to achieve an appropriate treatment that reduces its infectivity -the capacity of pathogens to invade organisms and cause infections-, since its composition of variants could determine how infection would develop in each patient.
Researchers of the University of Malaga (UMA) will be able to examine the depth of these spectra by genetic ultrasequencing techniques thanks to the innovative system they have designed: QuasiFlow , a tool that enables the analysis of variants present in each patient individually. ....

Spain General , Gonzalo Claros , Miguel Hern , Pedro Seoane , Emily Henderson , Isabel Viciana , Enrique Viguera , Gregorio Fern , Diego Lozano , Department Of Cellular Biology , University Of Elche , Centre For Molecular Biology Severo Ochoa , Researchers Of The University Malaga , Spanish National Research Council , Fund Of The Government Andalusia , Professor Ana Grande , Cellular Biology , Dana Grande , Virgen De La Victoria University Hospital , Malaga Jes , Ugo Bastolla , Molecular Biology , Corona Virus , Sars Cov 2 , ஸ்பெயின் ஜநரல் , கோன்சலோ கிளாரோஸ் ,