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20 days later -- The short story about muscles regeneration


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IMAGE: Two decades ago, tissue printing was like science fiction. Today it is the beginning of a real revolution in medicine. Photo taken at Sygnis New Technologies.
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Credit: Source: IPC PAS, Grzegorz Krzyzewski
Skeletal muscles make a tremendous variety of actions stabilizing the body in different positions. Despite their endurance during daily activities, they can undergo several mild injuries caused by sport, accidental overstretching, or sudden overtwisting. Luckily mild injuries can be quickly healed; however, when a large part of muscles is damaged or resected surgically, the full recovery can be impossible. Muscle regeneration is challenging, but the development of innovative biocompatible materials tackles that problem. Recently, a multinational team of scientists led by dr. Marco Costantini from the Institute of Physical Chemistry, Polish Academy of Sciences (IPC PAS), and dr. Cesare Gargioli from the University of Rome Tor Verg ....

Cesare Gargioli , Marco Costantini , National Science Centre Poland , University Of Rome Tor Vergata , Academy Of Sciences , Institute Of Physical Chemistry , Physical Chemistry , Polish Academy , Rome Tor Vergata , மார்கோ கோஸ்டாண்டினி , தேசிய அறிவியல் மையம் போல்யாஂட் , கலைக்கழகம் ஆஃப் அறிவியல் , நிறுவனம் ஆஃப் உடல் வேதியியல் , உடல் வேதியியல் , போலீஷ கலைக்கழகம் ,

Novel RNA factors may help cancer cells thrive


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Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease. Certain groups of genes are supposed to help cells along the path to maturity, leaving their youthful stemness behind. This requires sweeping changes in the microRNAome the world of small non-coding material, known as microRNAs, that control where and when genes are turned on and off. Many microRNAs are tumor-suppressive; in cancer, the microRNAome is distorted and disrupted. Recent work by researchers at Brigham and Women s Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. Findings are published in ....

Agnieszka Bronisz , Jakub Godlewski , Peter Pan , Antonio Chiocca , National Cancer Institute , National Science Center Poland , Brigham Department Of Neurosurgery , Like Peter Pan , Mossakowski Medical Research Centre , Polish Academy , Science Advances , ஜாகுப் கோதிளேவ்ஸ்கி , பீட்டர் பான் , அன்டோனியோ சியோகா , தேசிய புற்றுநோய் நிறுவனம் , தேசிய அறிவியல் மையம் போல்யாஂட் , ப்ரிகாம் துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சை , போன்ற பீட்டர் பான் , போலீஷ கலைக்கழகம் ,