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Engineered 'off the shelf' stem cells target breast cancer that metastasizes to the brain

Credit: Khalid Shah lab, Brigham and Women s Hospital
Approximately 15-to-30 percent of patients with metastatic breast cancer have brain metastasis (BM), with basal-like breast cancer (BLBC) metastasizing to the brain most frequently. The prognosis for BLBC-BM patients is poor, as the blood-brain barrier prevents most therapeutics from reaching the brain. Testing candidate therapies in clinical trials is also challenging because animal models that mimic BM are limited. In a new study, researchers from Brigham and Women s Hospital and collaborators engineered a bimodal tumor-suppressing and killing molecule that can be delivered to the brain by stem cells. They tested the therapy in three new mouse models of BLBC-BM that imitate human cancers and found that it successfully prolonged the lifespan of the mice. Findings are published in ....

Khalid Shah , Kanzawa Medical Research Foundation , Research Fellowships , Drug Administration , Brigham Department Of Neurosurgery , Uehara Memorial Foundation , Stem Cell Therapeutics , Overseas Research Fellowships , Kanzawa Medical Research , Medicine Health , Breast Cancer , காலிட் ஷா , ஆராய்ச்சி கூட்டுறவு , ப்ரிகாம் துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சை , ஊஎர நினைவகம் அடித்தளம் , தண்டு செல் சிகிச்சை , ஓவர்‌ஸீஸ் ஆராய்ச்சி கூட்டுறவு , மருந்து ஆரோக்கியம் , மார்பக புற்றுநோய் ,

Study: Cancer cells thrive due to Novel RNA factors

Study: Cancer cells thrive due to Novel RNA factors
ANI |
Updated: Jan 16, 2021 22:45 IST
Washington [US], January 16 (ANI): During recent research it was found that Nucleic circ2082 disrupts the microRNA assembly line in glioblastoma cancer cells, making it a potential upstream target for cancer treatment.
The research conducted at Brigham and Women s hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. ....

United States , Agnieszka Bronisz , Jakub Godlewski , Peter Pan , Antonio Chiocca , Brigham Department Of Neurosurgery , Mossakowski Medical Research Centre , Polish Academy , Cancer Cells , Novel Rna Factors , Latest Science News , ஒன்றுபட்டது மாநிலங்களில் , ஜாகுப் கோதிளேவ்ஸ்கி , பீட்டர் பான் , அன்டோனியோ சியோகா , ப்ரிகாம் துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சை , போலீஷ கலைக்கழகம் , புற்றுநோய் செல்கள் , நாவல் ர்ந காரணிகள் , சமீபத்தியது அறிவியல் செய்தி ,

Novel RNA factors may help cancer cells thrive

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Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease. Certain groups of genes are supposed to help cells along the path to maturity, leaving their youthful stemness behind. This requires sweeping changes in the microRNAome the world of small non-coding material, known as microRNAs, that control where and when genes are turned on and off. Many microRNAs are tumor-suppressive; in cancer, the microRNAome is distorted and disrupted. Recent work by researchers at Brigham and Women s Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. Findings are published in ....

Agnieszka Bronisz , Jakub Godlewski , Peter Pan , Antonio Chiocca , National Cancer Institute , National Science Center Poland , Brigham Department Of Neurosurgery , Like Peter Pan , Mossakowski Medical Research Centre , Polish Academy , Science Advances , ஜாகுப் கோதிளேவ்ஸ்கி , பீட்டர் பான் , அன்டோனியோ சியோகா , தேசிய புற்றுநோய் நிறுவனம் , தேசிய அறிவியல் மையம் போல்யாஂட் , ப்ரிகாம் துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சை , போன்ற பீட்டர் பான் , போலீஷ கலைக்கழகம் ,