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Patient-provider discussions about bariatric surgery play pivotal role in weight loss outcomes


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BOSTON Obesity increases one s risk for many diseases and often prevents patients from receiving other necessary medical procedures. One of the most effective ways for patients with severe obesity to lose weight is through bariatric surgery, but it s not clear how often this option is raised. In a new study published in
Obesity, investigators from Brigham and Women s Hospital find that eligible patients who discuss bariatric surgery options with their primary care providers or specialists from disciplines ranging from cardiology to urology are more likely to undergo surgery and lose more weight than those who do not have such discussions. But the team also found that these pivotal discussions were exceedingly rare, with fewer than 10 percent of eligible patients having a conversation over the course of a year. ....

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Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure


Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure
Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet. As heart failure progresses, the heart itself becomes increasingly unable to contract effectively, owing to changes in the molecules that control the heart, particularly a small gaseous molecule called nitric oxide.
Nitric oxide is carried by red blood cells and acts as a signal to relax arteries and increase blood flow to heart tissue. It is also produced within heart cells, where it chemically combines with proteins in a process known as S-nitrosylation. More than 20,000 known S-nitrosylation events turn proteins on or off, including proteins that make up the heart s beta-adrenergic receptor (βAR) system - the system that regulates the fight-or-flight respo ....

Walterj Koch , Jonathans Stamler , Emily Henderson , Sylviak Reitman Family Foundation , University Hospitals In Cleveland , National Institutes Of Health Heart Lung , Department Of Pharmacology , Blood Institute , Case Western Reserve University School Of Medicine , Lewis Katz School , Temple University , Case Western Reserve University School , University Hospitals , National Institutes , Health National Heart Lung , Endowed Chair , Cardiovascular Medicine , Translational Medicine , Family Foundation Distinguished Chair , Cardiovascular Innovation , Transformative Molecular Medicine , Harrington Discovery Institute , University Hospitals Cleveland Medical , Heart Failure , Nitric Oxide , Red Blood Cells ,