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Study reveals link between changes of neuronal activities and dyskinesia


Study reveals link between changes of neuronal activities and dyskinesia
Many people with Parkinson s disease develop abnormal movements called L-DOPA induced dyskinesia, a major side effect of long-term medication. The mechanism underlying this side effect has been unknown. In this study, researchers have revealed relation between changes of neuronal activities and dyskinesia.
Parkinson s disease (PD) is the common age-related neurological disorder affecting 7 - 10 million people worldwide.
It is caused by loss of dopaminergic neurons in the brain region called the substantia nigra, and induces difficulty in execution of movements (akinesia), muscle stiffness (rigidity), walking difficulty, tremorous hand movements (tremor), and non-motor symptoms such as depression and sleep disturbance. ....

Atsushi Nambu , Emily Henderson , National Institute For Physiological Sciences , National Institute , Physiological Sciences , Study Corresponding Author , எமிலி ஹென்டர்சன் , தேசிய நிறுவனம் க்கு உடலியல் அறிவியல் , தேசிய நிறுவனம் , உடலியல் அறிவியல் ,

Mechanism of abnormal movements induced by drug treatment of Parkinson's disease

Mechanism of abnormal movements induced by drug treatment of Parkinson's disease
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Atsushi Nambu , National Institute For Physiological Sciences , National Institute , Physiological Sciences , தேசிய நிறுவனம் க்கு உடலியல் அறிவியல் , தேசிய நிறுவனம் , உடலியல் அறிவியல் ,

New method could democratize deep learning-enhanced microscopy


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VIDEO: A low-resolution time-lapse of a mitochondrial network (cell s powerhouse) inside a cancer cell (left) is enhanced using artificial intelligence (right). Inset at bottom left highlights a fission (splitting) event that.
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Credit: Salk Institute/Waitt Advanced Biophotonics Core
LA JOLLA (March 8, 2021) Deep learning is a potential tool for scientists to glean more detail from low-resolution images in microscopy, but it s often difficult to gather enough baseline data to train computers in the process. Now, a new method developed by scientists at the Salk Institute could make the technology more accessible by taking high-resolution images, and artificially degrading them. ....

United States , Seungyoonb Yu , Kyle Kastner , Yoshiyuki Kubota , Alaa Abdel Latif , Jeremy Howard , Carar Schiavon , Fred Monroe , Gulcin Pekkurnaz , Zhao Zhang , Sammy Weiser Novak , Lindsey Kirk , Zijun Lin , Linjing Fang , Melissa Wu , Kristen Harris , Andrew Shaw , Waitt Foundation , University Of San Francisco , National Institute Of Health , National Cancer Institute , Chan Zuckerberg Initiative , National Science Foundation , National Institute For Physiological Sciences , National Institute On Deafness , Wicklow Ai Medical Research Initiative ,