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BOLD-100 Exhibits Potent Anti-Tumor Activity in Validated I/O In Vivo Models

BOLD-100 Exhibits Potent Anti-Tumor Activity in Validated I/O In Vivo Models
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British Columbia , Jiansu Hengrui Airuika , E Russell Mcallister , Merck Keytruda , Bold Therapeutics Inc , Bold Therapeutics , Jiansu Hengrui , பிரிட்டிஷ் கொலம்பியா , ஏ ரஸ்ஸல் மக்யாலிஸ்டர் , தைரியமான சிகிச்சை இன்க் , தைரியமான சிகிச்சை ,

BOLD-100 Exhibits Potent Anti-Tumor Activity in Validated I/O In Vivo Models

BOLD-100 Exhibits Potent Anti-Tumor Activity in Validated I/O In Vivo Models
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

British Columbia , Jiansu Hengrui Airuika , E Russell Mcallister , Merck Keytruda , Bold Therapeutics Inc , Bold Therapeutics , Jiansu Hengrui , பிரிட்டிஷ் கொலம்பியா , ஏ ரஸ்ஸல் மக்யாலிஸ்டர் , தைரியமான சிகிச்சை இன்க் , தைரியமான சிகிச்சை ,

Bold Therapeutics Receives FDA Clearance to Add U.S. Sites for Phase 1b / 2a Trial of BOLD-100 in the Treatment of Advanced GI Cancers

Bold Therapeutics Receives FDA Clearance to Add U.S. Sites for Phase 1b / 2a Trial of BOLD-100 in the Treatment of Advanced GI Cancers
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United States , British Columbia , E Russell Mcallister , Petr Kavan , Elaine Mcwhirter , Grainne Okane , Rachel Goodwin , Los Angeles , Jim Pankovich , Jamil Asselah , Jennifer Spratlin , University Of California , Juravinski Cancer Centre , Drug Administration , Princess Margaret Cancer Centre , Cross Cancer Institute In Edmonton , Bold Therapeutics Inc , Life Sciences Healthcare , Clinical Development , Bold Therapeutics , Investigational New Drug Application , Moffitt Cancer Center , Research Institute , Cross Cancer Institute , Ottawa General Hospital , Jewish General Hospital ,

Bold Therapeutics' BOLD-100 Effective In Vitro Against COVID-19 Variants

Bold Therapeutics Inc.
While viral mutations are inevitable, the potential for mutations to reduce the effectiveness of vaccines or potentially even render them ineffective is a source of considerable concern, particularly in countries with a vaccination-centric strategy. For example, the E484K mutation, first detected in both the South African (B.1.351) and Brazilian (B.1.1.28) variants – and more recently in the UK variant (B.1.1.7) – is a spike protein mutation that has been shown to be immune-evading, allowing previously infected patients to become reinfected and potentially allowing vaccinated patients to become infected. In just the past few weeks, a new Eek variant of concern (with both E484K and N501Y mutations) has emerged in Japan ....

United Kingdom , Western University , United States , British Columbia , South Africa , South African , E Russell Mcallister , Deena Hinshaw , University Of British Columbia , Bold Therapeutics Inc , Bold Therapeutics , Bold Therapeutic , Provincial Chief Medical Officer , National Research Council , Canada Industrial Research Assistance Program , ஒன்றுபட்டது கிஂக்டம் , மேற்கு பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , பிரிட்டிஷ் கொலம்பியா , ஏ ரஸ்ஸல் மக்யாலிஸ்டர் , தீனா ஹின்ஷா , பல்கலைக்கழகம் ஆஃப் பிரிட்டிஷ் கொலம்பியா , தைரியமான சிகிச்சை இன்க் , தைரியமான சிகிச்சை , மாகாண தலைமை மருத்துவ அதிகாரி , தேசிய ஆராய்ச்சி சபை ,

BOLD-100 MoA Research to Be Presented at the AACR Annual Meeting

Queen s University Belfast, Northern Ireland
Van Schaeybroeck s AACR poster presentation Targeting the DNA repair pathway with BOLD-100 in BRAF-mutant colorectal cancer (Poster# 1183, Session PO.ET04.03 on April 10) highlights the promising research conducted by the Drug Resistance Group at the Patrick G. Johnston Centre for Cancer Research at Queen s University Belfast, which investigated BOLD-100 s mechanism-of-action and identified promising treatment combinations in difficult-to-treat BRAF-mutant colorectal cancers.
Colon cancer is one of the most frequently diagnosed malignancies in adults, responsible for approximately 11% of all new cases of cancers worldwide and one-third of cancer deaths. BRAF-mutant colorectal cancers comprise 10% of those patients, and this subgroup has morphological, clinical, and therapeutic characteristics that differ substantially from patients without this genetic alteration. Importantly, there is no established standard of care for BRAF- ....

United States , United Kingdom , South Korea , British Columbia , Mark Bazett , E Russell Mcallister , Sandra Van Schaeybroeck , Van Schaeybroeck , Drug Resistance Group , Preclinical Development At Bold Therapeutics , Bold Therapeutics Inc , Phd Queen University Belfast , Bold Therapeutics , University Belfast , Cancer Research , Preclinical Development , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , தெற்கு கொரியா , பிரிட்டிஷ் கொலம்பியா , ஏ ரஸ்ஸல் மக்யாலிஸ்டர் , தைரியமான சிகிச்சை இன்க் , தைரியமான சிகிச்சை , பல்கலைக்கழகம் பெல்ஃபாஸ்ட் , புற்றுநோய் ஆராய்ச்சி ,