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Brain's THC equivalent can quell seizures but there's a catch

Brain's THC equivalent can quell seizures but there's a catch
futurity.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from futurity.org Daily Mail and Mail on Sunday newspapers.

Ivan Soltesz , Yulong Li , National Natural Science Foundation Of China , National Institutes Of Health , Stanford University School Of Medicine , Municipal Science Technology Commission , University School Of Life Sciences , Canadian Institutes Of Health Research , University Of Calgary , Vanderbilt University , Stanford University School , Peking University , National Institutes , Canadian Institutes , Health Research , Beijing Municipal Science , Technology Commission , National Natural Science Foundation , Peking University School , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , நகராட்சி அறிவியல் தொழில்நுட்பம் தரகு , பல்கலைக்கழகம் பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , கனடியன் நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் கல்கரி ,

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults


See eTable 1 in Supplement 2 for definitions of each analysis population. Among those receiving aluminum hydroxide (alum) for the first dose, 5 participants received WIV04 (n = 2) and HB02 (n = 3) vaccines for the second dose and were not included in the safety analysis population of the alum-only group (13 458 – 5 = 13 453), but were included in the WIV04 and HB02 groups, respectively. Three participants who received WIV04 for the first dose and HB02 for the second dose and 3 participants who received HB02 for the first dose and WIV04 for the second dose were included in both groups (WIV04: 13 459 + 2 + 3 = 13 464; HB02: 13 465 + 3 + 3 = 13 471). To measure neutralization antibody levels, the first 900 participants from each study site were selected. There were 9 participants in the WIV04 group, 7 in the HB02 group, and 8 in alum-only group who had adverse events or serious adverse events (SAEs) after the first dose and did not receive the se ....

United Arab Emirates , United Kingdom , Ministry Of Health , Al Qahirah , South Africa , Ash Shariqah , Abu Dhabi , Abuz Aby , World Health Organization , Jianxing Qiu , Al Mazrouei , Yuntao Zhang , Jielai Xia , Tal Karam , Al Qahtani , Bassam Mahboub , Xiaoming Yang , Jameela Alsalman , Dala Al Mansoori , Al Nusair , Al Kaabi , Jinming Li , Xuanyi Wang , Xingwang Li , Yanbo Zhang , Saifuddin Fasihuddin ,

Normally harmless cell molecule triggers neuron death


Credit: Wanli Liu
A vital intermediate in normal cell metabolism is also, in the right context, a trigger for cell death, according to a new study from Wanli Liu and Yonghui Zhang of Tsinghua University, and Yong Zhang of Peking University in Beijing, publishing 26th April 2021 in the open access journal PLOS biology. The discovery may contribute to a better understanding of the damage caused by stroke, and may offer a new drug target to reduce that damage.
Farnesyl pyrophosphate (FPP) is an intermediate in the mevalonate pathway, a series of biochemical reactions in every cell that contributes to protein synthesis, energy production, and construction of cell membranes. During a search for regulators of immune cell function, the authors unexpectedly discovered that FPP, when present at high concentrations outside of cells, caused rapid and extensive death of cells. FPP carries both a highly charged phosphate head and a long hydrophobic hydrocarbon tail, and by altering eac ....

United States , Yonghui Zhang , Yong Zhang , Wanli Liu , Tsinghua Center , National Natural Science Foundation Of China , China Postdoctoral Science Foundation , Innovation Center , National Institutes Of Health , Uaeu Tsinghua Asian Universities Alliance , Natural Science Foundation , Municipal Science Technology Commission , Life Sciences , Institute For Immunology , National Natural Science Foundation , Tsinghua University , National Key Rd Program Of China , Peking University , Tsinghua Asian Universities Alliance Joint Grant , Beijing Natural Science Foundation , Beijing Advanced Innovation Center , Beijing Municipal Science , Technology Commission , National Institutes , Postdoctoral Fellowship , Peking Tsinghua Center ,

Scientists reveal origin of neuronal diversity in hypothalamus


Credit: IGDB
A mechanistic understanding of brain development requires a systematic survey of neural progenitor cell types, their lineage specification and maturation of postmitotic neurons. Cumulative evidences based on single-cell transcriptomic analysis have revealed the heterogeneity of cortical neural progenitors, their temporal patterning and the developmental trajectories of excitatory and inhibitory neurons in the developing neocortex. Nevertheless, the developmental hierarchy of the hypothalamus, which contains an astounding diversity of neurons that regulate endocrine, autonomic and behavioral functions, has not been well understood.
Recently, however, Prof. WU Qingfeng s group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) conducted a study focusing on the origin of this neuronal diversity. For their work, they profiled the transcriptome of 43,261 hypothalamic neural cells to map the developmental landscape o ....

Strategic Priority Research Program , National Natural Science Foundation Of China , Institute Of Genetics , Municipal Science Technology Commission , National Key Rd Program Of China , Developmental Biology , Chinese Academy , Cell Stem , National Key Rd Program , National Natural Science Foundation , Beijing Municipal Science , மூலோபாய ப்ரையாரிடீ ஆராய்ச்சி ப்ரோக்ர்யாம் , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , நிறுவனம் ஆஃப் ஜெநெடிக்ஸ் , நகராட்சி அறிவியல் தொழில்நுட்பம் தரகு , தேசிய விசை ர்ட் ப்ரோக்ர்யாம் ஆஃப் சீனா , வளர்ச்சி உயிரியல் , சீன கலைக்கழகம் , செல் தண்டு , தேசிய விசை ர்ட் ப்ரோக்ர்யாம் , தேசிய இயற்கை அறிவியல் அடித்தளம் , பெய்ஜிங் நகராட்சி அறிவியல் ,