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2nd window ICG predicts gross-total resection/progression-free survival in brain metastasis


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IMAGE: A-E: The patient was infused intravenously with 5 mg/kg ICG approximately 24 hours before surgery. T1 MRI was performed with gadolinium at 1-mm resolution. The axial image (A) demonstrated a.
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Credit: Copyright 2021 AANS
Charlottesville, VA (March 2, 2021). Researchers in the Perelman School of Medicine at the University of Pennsylvania conducted a prospective cohort study utilizing their technique of delayed near-infrared imaging with high-dose indocyanine green (called second window ICG or SWIG ) in the identification of brain metastases during surgery. In this study, all metastatic lesions enhanced under near-infrared light with application of SWIG. The researchers compared near-infrared SWIG images obtained at the end of tumor resection with postoperative gadolinium-enhanced MRIs, considered the gold standard for imaging. The comparison demonstrated that SWIG can be used to predict the extent of gross-total resection and, m ....

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