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New study to examine the effects of MS disease-modifying therapy on cognitive fatigue

New study to examine the effects of MS disease-modifying therapy on cognitive fatigue
Kessler Foundation researchers have received support from Genentech, a member of the Roche Group, to conduct an investigator-initiated study on the effects of ocrelizumab (Ocrevus) on cognitive fatigue in individuals with relapsing-remitting multiple sclerosis (MS).
John DeLuca, PhD, senior vice president of Research and Training, is principal investigator for the study titled, A Biomarker for Cognitive Fatigue in MS using Functional Imaging . The study team includes Glenn Wylie, DPhil, director of the Rocco Ortenzio Neuroimaging Center at Kessler Foundation, Ekaterina Dobryakova, PhD, research scientist in the Center for Traumatic Brain Injury Research, and Helen Genova, PhD, assistant director of the Center for Neuropsychology and Neuroscience Research. ....

Helen Genova , Ekaterina Dobryakova , Glenn Wylie , John Deluca , Emily Henderson , Rocco Ortenzio Neuroimaging Center At Kessler Foundation , Kessler Foundation , Roche Group , Neuroscience Research , Ortenzio Center , Traumatic Brain Injury Research , Cognitive Fatigue , Rocco Ortenzio Neuroimaging Center , Medical School , Multiple Sclerosis , Relapsing Remitting Multiple Sclerosis , ஹெலன் ஜெனோவா , க்ளென் வைலீ , ஜான் டெழுகே , எமிலி ஹென்டர்சன் , கெஸ்லர் அடித்தளம் , ரோச் குழு , நரம்பியல் ஆராய்ச்சி , அதிர்ச்சிகரமான மூளை காயம் ஆராய்ச்சி , அறிவாற்றல் சோர்வு , மருத்துவ பள்ளி ,

Study implicates disruption in prenatal neurogenesis in the development of ASDs

Study implicates disruption in prenatal neurogenesis in the development of ASDs
A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized progenitor cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs). The study also shows that estrogen, perhaps in a form produced within brain cells, can protect against this disruption and steer the brain on a normal course of development.
The most striking findings in the study, published on January 25, 2021 in
Neuron, were derived from experiments using embryos of the western clawed frog (Xenopus tropicalis), a species prized by biologists for the unique insights it offers into development. Human genes involved in development have counterparts with similar functions in Xenopus, and extensive studies correlating human embryonic stages with those of the frog mean that genetic studies in Xenopu ....

Jeremy Willsey , Helen Rankin Willsey , Richard Harland , Helen Willsey , Emily Henderson , Institute For Neurodegenerative Diseases , Behavioral Sciences , Department Of Psychiatry , Weill Institute For Neurosciences , Weill Institute , Oberndorf Family Distinguished Professor , Distinguished Professor , Neurodegenerative Diseases , Rankin Willsey , Developmental Biology , Mental Health , ரிச்சர்ட் ஹார்‌ல்யாஂட் , எமிலி ஹென்டர்சன் , நடத்தை அறிவியல் , துறை ஆஃப் மனநல மருத்துவம் , வெயில் நிறுவனம் க்கு நரம்பியல் , வெயில் நிறுவனம் , ஓபேர்ந்தோற்ப் குடும்பம் புகழ்பெற்ற ப்ரொஃபெஸர் , புகழ்பெற்ற ப்ரொஃபெஸர் , மன இறுக்கம் , வளர்ச்சி உயிரியல் ,

Study shows how the brain quickly adjusts to group opinions

Study shows how the brain quickly adjusts to group opinions
Scientists at HSE University have learned that disagreeing with the opinion of other people leaves a trace in brain activity, which allows the brain to later adjust its opinion in favor of the majority-held point of view. The article was published in
Scientific Reports.
We often change our beliefs under the influence of others. This social behavior is called conformity and explains varios components of our behavior, from voting at elections to fashion trends among teenagers.
Brain research has recently well informed about short-term effects of social influence on decision making. If our choice coincides with the point of view of the people who are important to us, this decision is reinforced in the brain s pleasure centers involved in the larger dopaminergic system responsible for learning, motor activity and many other functions. Conversely, in instances of disagreement with others, the brain signals ....

Aleksei Gorin , Emily Henderson , University Professor Vasily Klucharev , Professor Vasily Klucharev , எமிலி ஹென்டர்சன் ,

New "molecular" tool helps shed light on individual synapses in brain cells

Optogenetics, or genetically engineering neurons to respond to light, is an important technique for studying how neurons work. However, manipulating individual synapses (gaps between neurons), where signaling transmission occurs, has been challenging until now. Researchers at National Institute of Physiological Sciences, Japan, have now generated a light-activated signaling protein that can help study signaling-related physiological changes in single neurons a breakthrough that will be valuable for neuroscience. ....

Hideji Murakoshi , Nature Communications , National Institute Of Physiological Sciences , National Institute , Physiological Sciences , Cell Biology , Medicine Health , Research Development , இயற்கை தகவல்தொடர்புகள் , தேசிய நிறுவனம் ஆஃப் உடலியல் அறிவியல் , தேசிய நிறுவனம் , உடலியல் அறிவியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , ஆராய்ச்சி வளர்ச்சி ,

MSK researchers learn what's driving 'brain fog' in people with COVID-19

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One of the dozens of unusual symptoms that have emerged in COVID-19 patients is a condition that s informally called COVID brain or brain fog. It s characterized by confusion, headaches, and loss of short-term memory. In severe cases, it can lead to psychosis and even seizures. It usually emerges weeks after someone first becomes sick with COVID-19.
In the February 8, 2021, issue of the journal
Cancer Cell, a multidisciplinary team from Memorial Sloan Kettering reports an underlying cause of COVID brain: the presence of inflammatory molecules in the liquid surrounding the brain and spinal cord (called the cerebrospinal fluid). The findings suggest that anti-inflammatory drugs, such as steroids, may be useful for treating the condition, but more research is needed. ....

United States , Jessica Wilcox , Jan Remsik , Sloan Kettering , Adrienne Boire , Department Of Neurology , Pershing Square Sohn Cancer Research Alliance , National Institutes Of Health , Terri Brodeur Breast Cancer Foundation Fellowship , Damon Runyon Cancer Research Foundation , Pathogenesis Program , American Brain Tumor Association Basic Research Fellowship , Druckenmiller Center , Lung Cancer Research , Cancer Cell , Memorial Sloan Kettering , Chief Fellow , Ask Clinical , Human Oncology , National Institutes , Pew Charitable Trusts , Lung Cancer , Medicine Health , Clinical Trials , Infectious Emerging Diseases , ஒன்றுபட்டது மாநிலங்களில் ,