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Janssen: Auf IMBRUVICA (Ibrutinib) basierende Kombinationstherapie als Erstlinienbehandlung von fester Dauer bei chronischer lymphatischer Leukämie zeigt hohe Raten der Krankheitskontrolle

Janssen: Auf IMBRUVICA (Ibrutinib) basierende Kombinationstherapie als Erstlinienbehandlung von fester Dauer bei chronischer lymphatischer Leukämie zeigt hohe Raten der Krankheitskontrolle
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Combo Therapy Boosts Response in Hairy Cell Leukemia


As pointed out by Tiacci and colleagues, the
BRAF V600E mutation is known to be the causal genetic event of HCL. Vemurafenib is a BRAF inhibitor, and while two studies showed it had activity in patients with refractory or relapsed HCL, relapses were common, with one study showing a median relapse-free survival of 9 months after the end of treatment.
Rituximab is myelotoxic and may complement intracellular BRAF inhibition in killing leukemic cells by means of a different mechanism, the authors explained.
This phase II single-center trial included 30 patients with refractory or relapsed HCL. Patients had previously received a median of three therapies. The study treatment regimen consisted of 8 weeks of oral vemurafenib (960 mg twice daily) and eight intravenous rituximab infusions (375 mg/m ....

United States , Michael Grever , Enrico Tiacci , Mike Bassett , University Of Perugia , Ohio State University In Columbus , Hairy Cell Leukemia Foundation , Lymphoma Society , New England Journal , Ohio State University , England Journal , Englj Med , Hairy Cell Leukemia , Chronic Leukemia , ஒன்றுபட்டது மாநிலங்களில் , மைக் பாசெட் , ஓஹியோ நிலை பல்கலைக்கழகம் இல் கொலம்பஸ் , ஹேரி செல் லுகேமியா அடித்தளம் , லிம்போமா சமூகம் , புதியது இங்கிலாந்து இதழ் , ஓஹியோ நிலை பல்கலைக்கழகம் , இங்கிலாந்து இதழ் , ஹேரி செல் லுகேமியா , நாள்பட்ட லுகேமியா ,