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Researchers explore early stages of ribosome formation to identify new targets for antibiotics


Researchers explore early stages of ribosome formation to identify new targets for antibiotics
Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process.
The formation of ribosomal components involves multiple helper proteins which, much like instruments in an orchestra, interact in a coordinated way. One of these helper proteins - protein ObgE - acts as the conductor, guiding the entire process. The research, which produced the first-ever image-based reconstruction of this process, has been published in
Molecular Cell.
Ribosomes are an essential component of all living cells. Frequently referred to as molecular protein factories , they translate genetic information into chains of linked-up amino acids which are otherwise known as proteins. ....

Baden Wuberg , Max Delbr , Christian Spahn , Rainer Nikolay , Emily Henderson , Institute For Medical Physics , University Of Konstanz , Max Planck Institute For Molecular Genetics , Study Last Author , Medical Physics , Molecular Medicine , Max Planck Institute , Molecular Genetics , Antibiotic Resistance , E Coli , Genetic Information , Living Cells , கிறிஸ்துவர் ஸ்பான் , மழை நிகோலே , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு மருத்துவ இயற்பியல் , படிப்பு கடந்த நூலாசிரியர் , மருத்துவ இயற்பியல் , மூலக்கூறு மருந்து , மூலக்கூறு ஜெநெடிக்ஸ் , நுண்ணுயிர்க்கொல்லி எதிர்ப்பு ,

Commonly used sweeteners may promote antibiotic resistance


Commonly used sweeteners may promote antibiotic resistance
Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.
The study found that the sweeteners saccharine, sucralose, aspartame, and acesulfame potassium all promoted horizontal transfer of the genes between bacteria in both environmental and clinical settings.
The sweeteners accelerated the exchange of antibiotic resistance genes (ARGs) via a process called conjugation. The genes are transferred from donor to recipient bacteria, which may then go on to develop multidrug resistance, says Zhigang Yu and colleagues from The University of Queensland in St. Lucia, Brisbane. ....

Zhigang Yu , Sally Robertson , University Of Queensland , Antibiotic Resistance , Antimicrobial Resistance , Cell Membrane , Dna Damage , Gene Transfer , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , நுண்ணுயிர்க்கொல்லி எதிர்ப்பு , ஆண்டிமைக்ரோபியல் எதிர்ப்பு , செல் சவ்வு , டீயெநே சேதம் , கீந் பரிமாற்றம் ,

Scientists Use Weather Radar Tech to Watch Storms of Microbes Brew Inside Cells


Scientists Use Weather Radar Tech to Watch Storms of Microbes Brew Inside Cells
28 FEBRUARY 2021
Scientists are using a radar-like weather system to watch as a storm of pathogens brew inside living tissue.
The strategy is entirely novel, according to the authors, and relies on a technique very similar to Doppler radars, which can detect the motion of precipitation and predict upcoming weather patterns.
 
Doppler ultrasounds, which use sound waves to create images of blood flow, are already used in the medical sphere, but this new technique can allow scientists to peek inside individual cells to see how they respond to pathogens like salmonella and ....

Michael Ladisch , David Nolte , Purdue University , Communications Biology , Rebecca Mcelhoe Purdue University , Amp Quot , டேவிட் நோல்ட் , பர்‌ட்யூ பல்கலைக்கழகம் , தகவல்தொடர்புகள் உயிரியல் , நுண்ணுயிர் எதிர்ப்பிகள் ,