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Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?


Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?
Research looking at the pathophysiology behind coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is ongoing. A team of researchers from Columbia University Vagelos College of Physicians & Surgeons, USA, present results linking oxidative stress and the activation of a biochemical pathway associated with Alzheimer’s disease to SARS-CoV-2 infection.
“In this study, we propose a potential mechanism that may contribute to systemic organ failure caused by SARS-CoV-2: defective Ca
2+ regulation and its downstream signaling,” wrote the researchers. “Of particular interest is that leaky RyR2 channels in the brain were associated with activation of neuropathological pathways that are also found in the brains of Alzheimer’s Disease patients.” ....

United States , Jocelyn Solis Moreirafeb , Jocelyn Solis Moreira , Columbia University Vagelos College Of Physicians Surgeons , Columbia University Vagelos College , Alzheimer Tau , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Oxidative Stress , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , முதுமறதி டா , கொரோனா வைரஸ் , நோயியல் இயற்பியல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , மன அழுத்தம் ,

Blood-clotting protein linked with tumor pathogenesis of CNS B-cell lymphoma


Blood-clotting protein linked with tumor pathogenesis of CNS B-cell lymphoma
In people with central nervous system (CNS) lymphoma, cancerous B cells a type of white blood cell accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels. This disease is quite rare, but individuals who are affected have limited treatment options and often experience recurrence.
Previous research has linked the severity of CNS lymphoma to abnormal leaks in the blood-brain barrier, a protective system that allows some substances to pass from the bloodstream to the brain, while blocking others. However, the specific molecular details of this link have been murky. ....

United States , Katerina Akassoglou , Justin Chan , James Rubenstein , Emily Henderson , University Of California , School Of Medicine , Helen Diller Family Comprehensive Cancer Center , Staff Research Scientist , Kyu Ryu , Senior Author , American Journal , Diller Family Comprehensive Cancer Center , Neurovascular Brain , Neurovascular Brain Immunology , Central Nervous System , Nervous System , Blood Vessels , Cns Lymphoma , White Blood Cell , ஒன்றுபட்டது மாநிலங்களில் , ஜஸ்டின் சான் , ஜேம்ஸ் ரூபன்ஸ்டீன் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பள்ளி ஆஃப் மருந்து ,

Cone snail venom could potentially treat severe forms of malaria


Cone snail venom could potentially treat severe forms of malaria
Plasmodium falciparum may be deadly even after treatment with current parasite-killing drugs. This is due to persistent cyto-adhesion of infected erythrocytes even though existing parasites within the red blood cells are dead.
As vaccines for malaria have proved less than moderately effective, and to treat these severe cases of
P. falciparum malaria, new avenues are urgently needed. Latest estimates indicate that more than 500 million cases of malaria and more than 400,000 deaths are reported worldwide each year
. Anti-adhesion drugs may hold the key to significantly improving survival rates.
Using venom from the ....

United States , Costa Rica , Frank Mar , Andrewv Oleinikov , Emily Henderson , National Institute Of Standard , Schmidt College Of Medicine , United States Department Of Commerce , Charlese Schmidt College Of Science , Florida Atlantic University , Florida Atlantic University Schmidt College Of Medicine , National Institute Of Standard Technology , Chemical Sciences Division , Schmidt College , National Institute , United States Department , Journalof Proteomics , Study Corresponding Author , Biomedical Science , Florida Atlantic , Plasmodium Falciparum , Red Blood Cells , ஒன்றுபட்டது மாநிலங்களில் , கோஸ்டா ரிக்கா , வெளிப்படையான மார் , எமிலி ஹென்டர்சன் ,