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Researchers identify proteins that contribute to the pathogenicity of COVID-19 virus


Researchers identify proteins that contribute to the pathogenicity of COVID-19 virus
Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease. Using advanced genetic engineering techniques developed at Texas Biomed, they systematically deleted the genetic code for five of the virus s accessory proteins, one at a time, to see how each one affected the virus s ability to spread and cause illness. The research was published online this month in the
Journal of Virology.
They found two proteins that seem to contribute most to the virus s pathogenicity, or ability to cause COVID-19 disease. When individually lacking those proteins, the virus did not replicate as much as the natural virus in cells, suggesting they play a critical role in its spread. In contrast, spread was not significantly reduced when the other proteins were deleted. ....

New York , United States , Luis Martinez Sobrido , Jesus Silvas , Emily Henderson , Icahn School Of Medicine At Mount Sinai , Texas Biomedical Research Institute , Texas Biomed , Study First Author , Texas Biomedical Research , Disease Intervention , Icahn School , Mount Sinai , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , கிறிஸ்தவ சமயத்தை தோற்றுவித்தவர் சில்வாஸ் , எமிலி ஹென்டர்சன் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , டெக்சாஸ் உயிர் மருத்துவ ஆராய்ச்சி நிறுவனம் , டெக்சாஸ் பயோமெட் , படிப்பு முதல் நூலாசிரியர் , டெக்சாஸ் உயிர் மருத்துவ ஆராய்ச்சி , நோய் தலையீடு , இக்ஹ்ன் பள்ளி , ஏற்ற சினை ,

Memory biomarkers confirm aerobic exercise helps cognitive function in older adults


Memory biomarkers confirm aerobic exercise helps cognitive function in older adults
ANI |
Updated: Jun 14, 2021 09:31 IST
Washington [US], June 14 (ANI): Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A recent study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training.
The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer s.
Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimer s disease (AD). In ageing humans, aerobic exercise training increases grey and white matter volume enhances b ....

United States , University Of Wisconsin , Ozioma Okonkwo , Henriette Van Praag , Wisconsin Alzheimer Disease Research Center , Schmidt College Of Medicine , Robic Exercise And Cognitive Health , Florida Atlantic University Schmidt College Of Medicine , Brain Institute , Institute For Human Health Disease Intervention , Department Of Medicine , Florida Atlantic University , Schmidt College , Wisconsin Alzheimer , Disease Research Center , Human Health , Disease Intervention , Aerobic Exercise , Older Adults , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் விஸ்கான்சின் , விஸ்கான்சின் முதுமறதி நோய் ஆராய்ச்சி மையம் , ஶ்மிட் கல்லூரி ஆஃப் மருந்து , புளோரிடா அட்லாண்டிக் பல்கலைக்கழகம் ஶ்மிட் கல்லூரி ஆஃப் மருந்து , மூளை நிறுவனம் , துறை ஆஃப் மருந்து ,