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A biotech's eye gene therapy faces longer odds as serious side effects pile up

A biotech's eye gene therapy faces longer odds as serious side effects pile up
biopharmadive.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from biopharmadive.com Daily Mail and Mail on Sunday newspapers.

Laurent Fischer , Mani Foroohar , Dive Brief , Luca Issi , Annapurna Therapeutics , Avalanche Biotechnologies , பரிசு பெற்றவர் பிஷ்ஷர் , டைவ் சுருக்கமான , லூகா இஸீ , பனிச்சரிவு உயிரி தொழில்நுட்பங்கள் ,

Genascence Announces Completion of Dosing and Interim Safety Data for Phase 1 Clinical Trial of GNSC-001 in Osteoarthritis

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PALO ALTO, Calif., May 5, 2021 /PRNewswire/
Genascence Corporation, a clinical-stage biotechnology company developing life-changing gene therapy products for prevalent musculoskeletal diseases, today announced that dosing across all three cohorts has been completed in the Phase 1 clinical trial of GNSC-001 for the treatment of osteoarthritis (OA).
GNSC-001 is an adeno-associated vector (AAV) carrying a coding sequence for interleukin-1 receptor antagonist (IL-1Ra), a potent inhibitor of interleukin-1 (IL-1) signaling. IL-1 is considered one of the key mediators involved in the pathogenesis of OA, causing inflammation as well as cartilage destruction. GNSC-001 is designed to offer long-term, sustained inhibition of IL-1 following a single injection into the affected joint. ....

United States , Palo Alto , Stanford University , Paul Robbins , Philip Conaghan , Steven Ghivizzani , Mukundan Attur , John Fraser Wright , Christopher Evans , Thomas Chalberg , Christopherh Evans , Annahita Keravala , Langone Health , Scientific Co , Rocket Pharmaceuticals , University Of Florida , Grossman School Of Medicine , American Society Of Gene , University Of Minnesota , University Of Leeds , Genascence Corporation , University Of Florida College Medicine , American Society , Cell Therapy , Annual Meeting , Osteoarthritis Gene Therapy ,

Gene therapy startup Genascence emerges with potential knee treatment - San Francisco Business Times

Gene therapy startup Genascence emerges with potential knee treatment - San Francisco Business Times
bizjournals.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bizjournals.com Daily Mail and Mail on Sunday newspapers.

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A serious side effect puts a biotech's eye gene therapy in limbo

Dive Brief:
A clinical trial participant who received a high dose of an experimental gene therapy for diabetic macular edema suffered a serious side effect, causing the treatment s developer, Adverum Biotechnologies, to immediately unmask the Phase 2 study.
Adverum said the trial volunteer had vision loss, inflammation and a decrease in eye pressure about 7.5 months after treatment with the gene therapy, known as ADVM-022. The company has notified regulators of the event, and aims to determine whether the gene therapy is to blame. Adverum said it s also looking into which other patients may be at risk of a similar side effect. ....

Mani Foroohar , Drug Administration , Dive Brief , Adverum Biotechnologies , Bluebird Bio , Molecular Partners , Annapurna Therapeutics , Avalanche Biotechnologies , டைவ் சுருக்கமான , நீல பறவை உயிர் , மூலக்கூறு கூட்டாளர்கள் , பனிச்சரிவு உயிரி தொழில்நுட்பங்கள் ,

Adverum Files Investor Presentation Highlighting Significant Strategic Progress and Purpose-Built Board to Oversee Stockholder Value Creation

Adverum Files Investor Presentation Highlighting Significant Strategic Progress and Purpose-Built Board to Oversee Stockholder Value Creation
Urges Stockholders to Vote the
WHITE Proxy Card “FOR” ALL of Adverum’s Three Highly Qualified, Diverse and Independent Directors: Dawn Svoronos, Reed V. Tuckson, M.D. and Thomas Woiwode, Ph.D.
REDWOOD CITY, Calif., April 22, 2021 (GLOBE NEWSWIRE) Adverum Biotechnologies, Inc. (Nasdaq: ADVM), a clinical-stage gene therapy company targeting unmet medical needs in ocular and rare diseases, today announced that it has filed a new investor presentation with the U.S. Securities and Exchange Commission in connection with its 2021 Annual Meeting of Stockholders (“Annual Meeting”). The presentation is available at https://investors.adverum.com/shareholder-services/annual-meeting. ....

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