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Ultrasound Is a Useful Tool to Assess Disease Activity and Treatment Response in Giant Cell Arteritis

Ultrasound Is a Useful Tool to Assess Disease Activity and Treatment Response in Giant Cell Arteritis
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Birmingham Vasculitis Activity Score , பர்மிங்காம் வாஸ்குலிடிஸ் நடவடிக்கை மதிப்பெண் ,

Personalized Algorithm Helps Guide Rituximab Retreatment

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A personalized algorithm was developed by researchers in England to recommend retreatment with rituximab (Rituxan) among patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with the intention of preventing relapses while lowering the risks of infection.
In a multivariable analysis of 60 rituximab-treated patients with ANCA-associated vasculitis followed over a decade, predictors of a longer time to relapse were concomitant immunosuppression (HR 0.48, 95% CI 0.24-0.94,
P=0.034), complete response at 6 months (HR 0.24, 95% CI 0.12-0.50,
P ....

Jack Arnold , Nancy Walsh , Regina College In Newport , Leeds Institute Of Rheumatic , Peuropean League Against Rheumatism , Leeds Institute , Birmingham Vasculitis Activity Score , Salve Regina College , League Against , Granulomatosis With Polyangiitis , பலா அர்னால்ட் , நான்சி வால்ஷ் , ரெஜினா கல்லூரி இல் நியூபோர்ட் , லீட்ஸ் நிறுவனம் ஆஃப் வாத , ஐரோப்பிய லீக் எதிராக வாத நோய் , லீட்ஸ் நிறுவனம் , பர்மிங்காம் வாஸ்குலிடிஸ் நடவடிக்கை மதிப்பெண் , சால்வ் ரெஜினா கல்லூரி , லீக் எதிராக ,

InflaRx Announces Positive Topline Results for Vilobelimab from the U.S. Phase II ...

Press release content from Globe Newswire. The AP news staff was not involved in its creation.
InflaRx Announces Positive Topline Results for Vilobelimab from the U.S. Phase II .
InflaRx N.V.May 11, 2021 GMT
U.S. IXPLORE Phase II trial achieved its objective; vilobelimab was shown to be safe and well tolerated in patients with ANCA-associated vasculitis when added to current standard of care
EU IXCHANGE Phase II trial is fully enrolled with results expected by the end of 2021
JENA, Germany, May 11, 2021 (GLOBE NEWSWIRE) InflaRx (Nasdaq: IFRX), a clinical-stage biopharmaceutical company developing anti-inflammatory therapeutics by targeting the complement system, announced today positive topline results from its U.S. Phase II IXPLORE study with vilobelimab in patients with anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis, or AAV. ....

United States , Petera Merkel , Korinna Pilz , Katja Arnold , Andreas Jungfer , Laurie Doyle , Exchange Commission , Mc Services , Global Head Of Clinical Research , University Of Pennsylvania , Global Head , Clinical Research , Birmingham Vasculitis Score , Birmingham Vasculitis Activity Score , Ann Arbor , Chief Strategy Officer , ஒன்றுபட்டது மாநிலங்களில் , காடிய அர்னால்ட் , லாரி டாய்ல் , பரிமாற்றம் தரகு , ம்ஸீ சேவைகள் , உலகளாவிய தலை ஆஃப் மருத்துவ ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , உலகளாவிய தலை , மருத்துவ ஆராய்ச்சி , பர்மிங்காம் வாஸ்குலிடிஸ் நடவடிக்கை மதிப்பெண் ,

FDA Panel to Weigh Avacopan's Fate for ANCA Vasculitis

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An FDA advisory panel will consider whether to recommend approval of an oral C5a inhibitor for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with agency staff raising questions over the clinical meaningfulness of key study data.
On Thursday, the FDA s Arthritis Advisory Committee will discuss the application for avacopan in ANCA-associated vasculitis, an umbrella term for a group of small and medium-sized vasculitides associated with high morbidity and mortality. The two main subtypes of the disease being considered are granulomatosis with polyangiitis and microscopic polyangiitis.
In FDA briefing documents released ahead of the meeting, agency staff noted that the efficacy in the phase III trial supporting the potential approval was statistically significant, but that there were uncertainties about the interpretability of these data and the clinical meaningfulness of these results. ....

Arthritis Advisory Committee , Advisory Committee , New England Journal , Birmingham Vasculitis Activity Score , புதியது இங்கிலாந்து இதழ் , பர்மிங்காம் வாஸ்குலிடிஸ் நடவடிக்கை மதிப்பெண் ,

Avacopan Noninferior to Prednisone for ANCA-Associated Vasculitis

Feb 19, 2021
THURSDAY, Feb. 18, 2021 (HealthDay News) Avacopan is noninferior, but not superior, to prednisone with respect to remission at week 26 for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, according to a study published in the Feb. 18 issue of the
New England Journal of Medicine.
David R.W. Jayne, M.D., from Addenbrooke’s Hospital in Cambridge, United Kingdom, and colleagues randomly assigned 331 patients with ANCA-associated vasculitis to receive either oral avacopan or oral prednisone on a tapering schedule (166 and 165 patients, respectively). All patients received standard therapy for remission induction with either cyclophosphamide (followed by azathioprine) or rituximab.
The researchers found that in both groups, the mean Birmingham Vasculitis Activity Score (BVAS) at baseline was 16; the first primary end point (remission, defined as a BVAS of 0) was observed in 72.3 and 70.1 percent receiving avacopan and pred ....

United Kingdom , Davidrw Jayne , Healthday News , New England Journal , Birmingham Vasculitis Activity Score , ஒன்றுபட்டது கிஂக்டம் , புதியது இங்கிலாந்து இதழ் , பர்மிங்காம் வாஸ்குலிடிஸ் நடவடிக்கை மதிப்பெண் ,