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Liso-Cel Shows Promising Clinical Activity and Safety in CLL


Following is a transcript of their remarks:
Susan O Brien, MD: Hi, everyone, and welcome to this roundtable where we re going to discuss CLL presentations at ASH 2020 this year. I m Dr. Susan O Brien from the Chao Family Comprehensive Cancer Center at the University of California in Irvine, and I m joined by two esteemed colleagues, Dr. Jennifer Brown from Dana-Farber and Dr. Anthony Mato from Memorial Sloan Kettering.
We have two presentations today on the TRANSCEND clinical trial, and that is an interesting CAR-T trial of liso-cel which targets CD19, like many of the other CAR-Ts, but is a little bit different in that it has a defined component of CD4 and CD8 cells, which I think is the only CAR-T that s actually doing that. One of the presentations involved just the CAR-T alone and the other was the CAR-T given in combination with ibrutinib. Jennifer, maybe you could speak to that and the rationale for actually giving it with ibrutinib in the sense that many of the pati ....

New York , United States , University Of California Irvine , Susan Obrien , Jennifer Brown , Tait Shanafelt , Greg Laub , Jenniferr Brown , Sloan Kettering , Anthony Mato , American Society Of Hematology , University Of California , Chao Family Comprehensive Cancer Center , Program At Memorial Sloan Kettering Cancer Center , Center At Boston Dana Farber Cancer Institute , University Of California Irvine Health , American Society , Page Today , Moderator Susano Brien , California Irvine Health , Dana Farber Cancer Institute , Memorial Sloan Kettering Cancer Center , New York City , Medpage Today , Promising Efficacy , Susano Brien ,

Where U2 Will Fit in CLL Treatment Landscape?


Following is a transcript of their remarks:
Susan O Brien, MD: Hi, everyone, and welcome to this roundtable where we re going to discuss CLL presentations at ASH 2020 this year. I m Dr. Susan O Brien from the Chao Family Comprehensive Cancer Center at the University of California in Irvine, and I m joined by two esteemed colleagues, Dr. Jennifer Brown from Dana-Farber and Dr. Anthony Mato from Memorial Sloan Kettering.
An interesting presentation at ASH this year that many people were looking forward to was the trial looking at the combination of what s called U2, which is a novel anti-CD20 antibody, ublituximab, combined with a novel PI3K delta inhibitor, umbralisib. In this randomized trial, the comparator arm was obinutuzumab with chlorambucil and it was interesting because the trial actually included both previously untreated as well as previously treated patients. Jennifer, do you want to talk about some of the results from this trial? ....

New York , United States , University Of California Irvine , Susan Obrien , Jennifer Brown , Greg Laub , Jenniferr Brown , Sloan Kettering , Anthony Mato , American Society Of Hematology , University Of California , Chao Family Comprehensive Cancer Center , Program At Memorial Sloan Kettering Cancer Center , Center At Boston Dana Farber Cancer Institute , University Of California Irvine Health , American Society , Page Today , Moderator Susano Brien , California Irvine Health , Dana Farber Cancer Institute , Memorial Sloan Kettering Cancer Center , New York City , Medpage Today , Susano Brien , Memorial Sloan , Production Manager ,

'Our Nurses Are the True Superheroes': What We Heard This Week


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So our marketing team said Why don t we pitch Marvel that our nurses are the true superheroes? Claire Zangerle, RN, chief nurse executive at Allegheny Health Network in Pittsburgh, on the origin story of the comic book that gave front-line nurses a Marvel makeover.
I m scared to death. Gail Engel, age 65, founder and administrator of the Grand Family Coalition in Colorado, on the threat of COVID-19 infection she faces as an older caretaker raising her grandson.
These are patients that we may not be thinking about that may be at risk of substance abuse. Carlos Arteaga, MD, of the University of Texas Southwestern School of Medicine in Dallas, discussing research about persistent opioid use in women following breast cancer surgery. ....

United States , New York , University Of Texas , Susan Obrien , Gail Engel , Carlos Arteaga , Jim Czarniak , Claire Zangerle , Douglas Waite , Family Services , Bronxcare Health System , University Of Texas Southwestern School Medicine , Onondaga County Department Of Children , Allegheny Health Network In Pittsburgh , Family Coalition , University Of California Irvine Health , Allegheny Health Network , Grand Family Coalition , Texas Southwestern School , California Irvine Health , Onondaga County Department , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் , சூசன் ஓபிறீேன் , கெயில் ஏங்கல் ,

CLL at ASH 2020: The CAPTIVATE trial


At December s
has brought together three expert leaders in their field:
Moderator Susan O Brien, MD, of Chao Family Comprehensive Cancer Center, University of California Irvine Health, is joined by Jennifer R. Brown, MD, Director of the CLL Center at Dana-Farber Cancer Institute, and Anthony Mato, MD, Director of the CLL Program at Memorial Sloan Kettering Cancer Center, for a virtual roundtable discussion on the new and potentially practice-changing data from the meeting.
In this first of four exclusive MedPage Today
episodes, the discussion centers on the studies focused on combined ibrutinib plus venetoclax therapy, including the phase II CAPTIVATE study. ....

University Of California Irvine , United States , Susan Obrien , Jennifer Brown , Greg Laub , Jenniferr Brown , Sloan Kettering , Anthony Mato , University Of California , American Society Of Hematology , Center At Dana Farber Cancer Institute , Chao Family Comprehensive Cancer Center , Program At Memorial Sloan Kettering Cancer Center , University Of California Irvine Health , Page Today , Moderator Susano Brien , California Irvine Health , Dana Farber Cancer Institute , Memorial Sloan Kettering Cancer Center , Medpage Today , Susano Brien , Memorial Sloan , Production Manager , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா இவைந் , ஒன்றுபட்டது மாநிலங்களில் , சூசன் ஓபிறீேன் ,