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Cancer 'guardian' breaks bad with one switch

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IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone.
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Credit: Kolomeisky Research Group/Rice University
HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called the guardian of the genome, is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors. ....

University Of Houston , United States , Rice University , University Of Texas , David Yang , Navin Varadarajan , Aram Davtyan , Stephen Greenwell , Michelle Barton , Mohsen Fathi , Arash Saeedi , Mike Williams , Alena Klindziuk , Peter Vekilov , Jeff Falk , Michael Sherman , Kolomeisky Research Group Rice University , Rice Department Of Chemistry , National Science Foundation , Kolomeisky Research Group , University Of Texas Medical Branch At Galveston , Anatoly Kolomeisky At Rice University , Baker Institute For Public , Oregon Health Science University , Research Institute Of Texas , University Of Texas Md Anderson Cancer Center ,

UTMB researchers pioneer a new way to study frustration as a factor in substance use disorders

UTMB researchers pioneer a new way to study frustration as a factor in substance use disorders
A team from The University of Texas Medical Branch at Galveston (UTMB) focused on drug addiction research have pioneered a new way to study frustration as a factor in substance use disorders. The study was published in the medical journal
Psychopharmacology.
Traditional addiction research has focused on three aspects of substance use disorders: craving, impulsivity, or habit. Scientists hypothesized that a fourth factor, frustration, could also lead to escalation of drug use and addiction.
The Psychopharmacology paper noted that research into the role of frustration and substance use disorders is sparse, but a number of studies suggest that persons with substance use disorders have lower frustration tolerance. Studies have shown that sensitivity to frustration correlates with relapse among those with substance use disorders. ....

Tileena Vasquez , Emily Henderson , University Of Texas Medical Branch At Galveston , Department Of Pharmacology , Texas Medical Branch , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை இல் கால்வெஸ்டன் , துறை ஆஃப் மருந்தியல் , டெக்சாஸ் மருத்துவ கிளை ,

New study suggests frustration could lead to escalation of drug use and addiction

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While traditional addiction research has focused on three aspects of substance use disorders, namely craving, impulsivity, or habit, a new study suggests that frustration could also lead to escalation of drug use and addiction. The new study published in the journal Psychopharmacology noted that research into the role of frustration and substance use disorders is sparse, but a number of studies suggest that persons with substance use disorders have lower frustration tolerance.
Studies have shown that sensitivity to frustration correlates with relapse among those with substance use disorders.
For the latest study, the researchers used a rat model to focus on frustration-related behaviour. ....

Thomas Green , Tileena Vasquez , University Of Texas Medical Branch At Galveston , Image Source , Texas Medical Branch , Drug Addiction , Drug Addict , Medical Study , தாமஸ் பச்சை , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை இல் கால்வெஸ்டன் , படம் மூல , டெக்சாஸ் மருத்துவ கிளை , மருத்துவ படிப்பு ,

Frustration could lead to drug addiction - INDIA New England News

Frustration could lead to drug addiction - INDIA New England News
indianewengland.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from indianewengland.com Daily Mail and Mail on Sunday newspapers.

New York , United States , Thomas Green , Tileena Vasquez , University Of Texas Medical Branch At Galveston , Texas Medical Branch , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , தாமஸ் பச்சை , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை இல் கால்வெஸ்டன் , டெக்சாஸ் மருத்துவ கிளை ,

COVID-19: Angina drug may be an effective treatment

COVID-19: Angina drug may be an effective treatment
Written by Erika Watts on February 26, 2021 Fact checked by Hilary Guite, FFPH, MRCGP
New research in cells shows the drug bepridil holds promise for treating COVID-19. filadendron/Getty Images
A recent study shows that bepridil a drug approved by the Food and Drug Administration (FDA) for treating heart angina but currently voluntarily withdrawn due to cardiac side effects may be highly effective in treating COVID-19.
The researchers tested 55 different FDA-approved medications. As many as 29 of these showed promise, and six were found to reduce activity of a crucial enzyme that helps the virus replicate. ....

United States , University Of Texas , Wenshe Ray Liu , Kent Tseng , University Of Texas Medical Branch At Galveston , Texasam University , Drug Administration , College Station , National Academy , Gradipore Chair , Chien Te Kent Tseng , Texas Medical Branch , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் , கேண்ட் ட்செங் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் மருத்துவ கிளை இல் கால்வெஸ்டன் , கல்லூரி நிலையம் , தேசிய கலைக்கழகம் , சீன் தே கேண்ட் ட்செங் , டெக்சாஸ் மருத்துவ கிளை ,