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Three UW–Madison students named 2021 Goldwater Scholars

Three UWâMadison students named 2021 Goldwater Scholars
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Three University of WisconsinâMadison students have been named 2021 winners of the Barry Goldwater Scholarship, considered the countryâs preeminent undergraduate scholarship in the natural sciences, mathematics and engineering.
UWâMadisonâs winners are Manasa Kalluri,Â Qianyun (Lexi) Luo andÂ Gage Siebert. All three are juniors. Each will receive up to $7,500 for their senior year of undergraduate study.
More than 1,250 students were nominated this year from 438 academic institutions; 410 were named Goldwater Scholars.
The scholarship program honors the late Sen. Barry Goldwater and was designed to develop highly qualified scientists, engineers and mathematicians. The scholarships were first awarded in 1989. ....

United States , Lee Eckhardt , Randall Kimple , Peter Timbie , David Baum , Qianyun Lexi Luo , Manasa Kalluri , Alexandre Reuben , Division Of Cardiovascular Medicine , University Of Texas Md Anderson Cancer Center , Wisconsin Institute For Discovery , Public Health , Madison Department Of Medicine , Molecular Arrhythmia Research Program , American Astronomical Society , Uw School Of Medicine , Madison Department , Cardiovascular Medicine , Molecular Arrhythmia Research , Cancer Center , Professor David Baum , Wisconsin Institute , Arecibo Observatory , Puerto Rico , American Astronomical , Professor Peter Timbie ,

'Patchwork' tumors prevalent across multiple cancer types

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Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analysed the whole genomes of tumour samples from over 2,600 patients with different types of cancer. They identified a high prevalence of genetic diversity within individual tumours, which they further characterised. Their findings confirm that, even at late stages of development, tumour evolution is driven by changes that benefit the cancer.
When cancer cells divide, errors occur in the process of copying their DNA. These copying errors mean that different tumours can be made up of cells presenting a wide range of genetic diversity. This variation is a challenge for doctors as a treatment that works for one group of genetically related tumour cells, called a subclone, may not be effective against another. And certain subclones can initiate tumour spread or drug resistance. ....

United Kingdom , United States , City Of , Maxime Tarabichi , Robert Waley Cohen , University College London , Broad Institute , King College London , Cancer Analysis Of Whole Genomes Consortium , University Of Toronto , Cancer Genomics Laboratory , Imperial College London , Winton Group Leader , Ontario Institute For Cancer Research , Research Council , University Of Texas Md Anderson Cancer Center , Big Data Institute At University Of Oxford , Wellcome Sanger Institute , Cancer Research United Kingdom , Biomedical Research Centre , Van Loo Lab , Francis Crick Institute , Vector Institute , University Of Leuven , Pan Cancer Analysis , Whole Genomes Consortium ,

Projects & Studies

Projects & Studies
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The Acute Effects of Exercise on Breast Cancer Biomarkers (ACE Study) is enrolling women to test the effect of moderate intensity exercise on cancer risk factors such as biomarkers in healthy women. Knowing if exercise significantly alters these biomarkers, could help support guidelines for daily exercise for breast cancer prevention and could indicate that exercise even without weight loss is beneficial.
Advanced Colorectal Cancer of Serrated Subtype (ACCESS) Study
Description
Funding Agency: National Institutes of Health
Advancing our Understanding of the Etiologies and Mutational Landscapes of Basal-like, Luminal A, and Luminal B Breast Cancer
Description
Addressing research gaps in the molecular subtypes of breast cancer, we are taking a multidisciplinary approach to study the epidemiology and mutational landscapes of basal-like, luminal A, and luminal B tumors. ....

University Of Washington , United States , Fred Hutch , Mark Thornquist , Mary Anne Rossing , National Cancer Institute , Research To Optimize The Screening Process , National Institutes Of Health Cancer Institute , Early Detection Research Network , Health Disparities , Colorectal Research In Epidemiology , Infectious Disease Sciences , Personalized Medicine Coalition , Breast Cancer Initiative , Ovary Cancer Clinical Validation Center , Public Health Sciences , Infectious Disease Division , National Institute On Minority Health , University Of Texas Md Anderson Cancer Center , Clinical Trials Network , National Institutes Of Health , Steering Committee , Healthy Community Together We , American Association For Cancer Research , Funding Agency , Acute Effects ,

Genetic diversity within tumors suggests continuous evolution

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Genetic diversity within tumors suggests continuous evolution
By analyzing tumors from more than 2,600 patients and from 38 cancer types, researchers from The University of Texas MD Anderson Cancer Center and fellow member institutions of the international Pan-Cancer Analysis of Whole Genomes Consortium have characterized the extensive genetic diversity across cancer and within individual tumors.
The study, published today in Cell, found that 95% of the analyzed tumors had at least one subclone, or genetically distinct group of tumor cells, and these subclones were often very diverse – even in the same tumor. The findings suggest that tumors continue to evolve in ways that help the cancer survive. ....

New York , United States , Memorial Sloan Kettering Cancer Center , United Kingdom , Quaidd Morris , Wenyi Wang , University Of Texas Md Anderson Cancer Center , University Of Oxford , Md Anderson Moon Shots Program , Cancer Analysis Of Whole Genomes Consortium , University Of Toronto , Cancer Genomics Laboratory , Francis Crick Institute , Cancer Center , Pan Cancer Analysis , Whole Genomes Consortium , Peter Van Loo , Francis Crick , Moon Shots Program , Ivan Loo , New York City , Whole Genomes , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , நினைவகம் ஸ்லோன் கெட்டரிங் புற்றுநோய் மையம் , ஒன்றுபட்டது கிஂக்டம் ,

Daiichi Sankyo Company, Limited: Phase 1/2 Trial Initiated for Daiichi Sankyo's Menin Inhibitor DS-1594 in Patients with Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia

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Daiichi Sankyo Company, Limited (hereafter Daiichi Sankyo) today announced the first patient has been dosed in the first-in-human phase 1/2 study of DS-1594, a selective small-molecule menin inhibitor, in adults with relapsed/refractory acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The trial is being conducted by The University of Texas MD Anderson Cancer Center under an existing strategic research collaboration.
Inhibition of the menin protein is being studied as a novel treatment approach for acute leukemias with MLL rearrangement (MLLr) or NPM1 mutation (NPM1m), two gene alterations that drive cancer development and growth.
1 MLLr occurs in approximately 5 to 10% of acute leukemia patients and is associated with aggressive disease, reduced treatment response and poor prognosis. ....

United States , Masashi Kawase , Arnaud Lesegretain , Daiichi Sankyo , Daiichi Sankyo Europe Gmb , Jennifer Brennan , Daiichi Sankyo Co Ltd , Plexxikon Inc , Daiichi Sankyo Inc , Daiichi Sankyo Company , University Of Texas Md Anderson Cancer Center , Daiichi Sankyo Group , Leukemia Lymphoma Society , Cancer Center , Vice President , Alpha Portfolio , Acute Myeloid Leukemia , Acute Lymphoblastic Leukemia , Daiichi Sankyo Cancer Enterprise , Sankyo Group , Pharma Innovator , Competitive Advantage , Population Fact Sheet , Updated November , Leukemia Facts , Acute Myeloid ,