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Antibodies to common cold coronaviruses do not protect against SARS-CoV-2


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PHILADELPHIA Past exposure to seasonal coronaviruses (CoVs), which cause the common cold, does not result in the production of antibodies that protect against the novel coronavirus SARS-CoV-2, according to a study led by Scott Hensley, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania.
Prior studies have suggested that recent exposure to seasonal CoVs protects against SARS-CoV-2, the virus that causes COVID-19. However, research from Hensley s team, published in
Cell, suggests that if there is such protection, it does not come from antibodies.
We found that many people possessed antibodies that could bind to SARS-CoV-2 before the pandemic, but these antibodies could not prevent infections, Hensley said. Although antibodies from prior coronavirus infections cannot prevent SARS-CoV-2 infections, it is possible that pre-existing memory B cells and T cells could potentially provide some level ....

University Of Pennsylvania , United States , Pennsylvania Hospital , New Jersey , Jeffrey Lurie , Alex Huang , Scott Hensley , Anurag Verma , Elizabeth Anderson , David Blitzer , Nuala Meyer , E John Wherry , Joel Embiid , Eileen Goodwin , Michael Betts , Josh Harris , Penn Medicine Princeton Health , National Institutes Of Health , Lancaster Behavioral Health Hospital , Penn Institute Of Immunology , Perelman School Of Medicine , University Of Pennsylvania Health System , Princeton House Behavioral Health , Ruth Perelman School Of Medicine , Laboratory Medicine , Hospital Of The University Pennsylvania ,

Stem cell study illuminates the cause of a devastating inherited heart disorder


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PHILADELPHIA Scientists in the Perelman School of Medicine at the University of Pennsylvania have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder.
This inherited form of DCM which affects at least several thousand people in the United States at any one time and often causes sudden death or progressive heart failure is one of multiple congenital disorders known to be caused by inherited mutations in a gene called
LMNA. The
LMNA gene is active in most cell types, and researchers have not understood why
LMNA mutations affect particular organs such as the heart while sparing most other organs and tissues. ....

University Of Pennsylvania , United States , Pennsylvania Hospital , New Jersey , Qiaohong Wang , Julie Heffler , Benjamin Prosser , Kiran Musunuru , Parisha Shah , Ricardo Linares Saldana , Dilip Thomas , Joseph Wu , Rajan Jain , Andrey Poleshko , Anjali Owens , Kenneth Bedi , Daniel Rader , Deepti Abbey , Joshua Rhoades , Nazish Sayed , Michael Morley , Kenneth Margulies , David Frank , Wenli Yang , Thomas Cappola , Matthew Caporizzo ,