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Connecting early response and later outcome in COVID-19, centenarians' unique microbiomes, T cell exhaustion in cancer, and more

Connecting early response and later outcome in COVID-19, centenarians' unique microbiomes, T cell exhaustion in cancer, and more
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Jon Rennhack , Vincent Miao , Ryan Tewhey , Catherine Wu , Pardis Sabeti , Chao Dai , Giacomo Oliveira , Sagar Gosai , Ramnik Xavier , Kathleen Yates , Alex Shalek , Steven Reilly , Kim Stegmaier , Nicholas Haining Merck , Anna Owings , Carly Ziegler , Hera Vlamakis , Bo Kyung Seong , Schmidt Fellowluke Oconnor , Damian Plichta , Broad Institute , Cancer Program , Microbiome Program , Keio University School Of Medicine , Research Roundup , Jackson Laboratory ,

University of Helsinki: Large genomic analysis highlights COVID-19 risk factors


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In March of 2020, thousands of scientists around the world united to answer a pressing and complex question: what genetic factors influence why some COVID-19 patients develop severe, life-threatening disease requiring hospitalization, while others escape with mild symptoms or none at all?
A comprehensive summary of their findings to date, published in Nature, reveals 13 loci, or locations in the human genome, that are strongly associated with infection or severe COVID-19. The researchers also identified causal factors such as smoking and high body mass index. These results come from one of the largest genome-wide association studies ever performed, which includes nearly 50,000 COVID-19 patients and two million uninfected controls. ....

Eteläuomen Läi , Mari Niemi , Landskapet Sodra Savolax , Andrea Ganna , Mark Daly , Ben Neale , Broad Institute , University Of Helsinki , Host Genetics Initiative , Institute For Molecular Medicine Finland , Genetics Initiative , Molecular Medicine Finland , Population Genetics , From Finland , East Asian , South Asian , ஆண்ட்ரியா கண்ணா , குறி டேலி , பென் நீல் , பரந்த நிறுவனம் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , தொகுப்பாளர் ஜெநெடிக்ஸ் முயற்சி , நிறுவனம் க்கு மூலக்கூறு மருந்து பின்லாந்து , ஜெநெடிக்ஸ் முயற்சி , மூலக்கூறு மருந்து பின்லாந்து , பாப்யுலேஶந் ஜெநெடிக்ஸ் ,