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Blood Test for Kidney Rejection Suggests New Treatment


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Blood Test for Kidney Rejection Suggests New Treatment
PITTSBURGH– Researchers at the University of Pittsburgh School of Medicine have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage.
These results, published today in Science Translational Medicine, not only identify a warning signal that something is going wrong, but also suggest an existing medication that could be given to these patients to right the course of their long-term recovery.
“We can’t tell a priori if a patient is on too much or too little immune suppression we don’t know until after rejection or an infection has already started,” said senior author David Rothstein, M.D., the Pittsburgh Steelers Chair in Transplantation and professor of surgery, medicine and immunology at Pitt. “We wanted to find something that would tell us this patient ....

United States , United Kingdom , City Of , David Rothstein , Aravind Cherukuri , Ciara Magee , Amit Tevar , Sundaram Hariharan , Hans Stauss , Alan Salama , Richard Baker , Rajil Mehta , Kanishka Mohib , Mark Harber , Fadi Lakkis , Douglas Landsittel , American Society Of Transplantation , National Institutes Of Health , University Of Pittsburgh School Medicine , National Institute For Health Research , Roche Organ Transplant Research Foundation , University College Of London , James University Hospital In Leeds , Thomase Starzl Transplantation Institute At Pitt , Pittsburgh School , Science Translational Medicine ,

Blood test for kidney rejection suggests new way to treat post-transplant patients


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IMAGE: Pittsburgh Steelers Chair in Transplantation and professor of surgery, medicine and immunology, University of Pittsburgh School of Medicine
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Credit: Thomas E. Starzl Transplantation Institute at the University of Pittsburgh
PITTSBURGH, Feb. 24, 2021 - Researchers at the University of Pittsburgh School of Medicine have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage.
These results, published today in
Science Translational Medicine, not only identify a warning signal that something is going wrong, but also suggest an existing medication that could be given to these patients to right the course of their long-term recovery. ....

United States , United Kingdom , City Of , Aravind Cherukuri , David Rothstein , Ciara Magee , Amit Tevar , Andrea Kunicky , Sundaram Hariharan , Hans Stauss , Alan Salama , Richard Baker , Rajil Mehta , Kanishka Mohib , Mark Harber , Fadi Lakkis , Douglas Landsittel , School Of Medicine , American Society Of Transplantation , University Of Pittsburgh School Medicine , National Institutes Of Health , Roche Organ Transplant Research Fund , National Science Foundation , National Institute For Health Research , University College Of London , Insurance Services Division ,