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PETALING JAYA: Many Malaysians are shocked by the collision between two trains in a tunnel here along the Kelana Jaya LRT line on Monday night (May 24). ....
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National Library in Minsk (by Alex XFollow) Our locals in Europe have written about many buildings that have earned a reputation for being the ugliest building in their city. These structures are hated by some, but many have grown to love them. We’ve selected 12 buildings around Europe that are considered “ugly” by residents or architects. It’s up to you to decide if you agree of course… Whether you love or you hate them, they can be interesting spots to visit for sure! National Library, Prishtina National library of Kosovo Prishtina (by Bart van Poll) The National Library of Kosovo is often referred to in lists as the “ugliest building in the world”. It definitely is truly bizarre. A bit like a game of Tetris has gone wrong. It was opened as part of the Albanian-language University of Prishtina. Many tried to figure out what the 99 white domes represented. Some say they are traditional Albanian hats, others think brains. ....
KUALA LUMPUR (May 3): Some analysts have revised up their target prices (TPs) and earnings forecasts for MR DIY Group (M) Bhd after its profit for the first quarter ended March 31, 2021 (1QFY21) beat their expectations. UOB Kay Hian analyst Philip Wong said in a note today MR DIY’s 1QFY21 earnings beat the research house s expectations on the back of its resounding in-store sales and accelerated store expansion. “We raise our FY21-23 revenue per store growth assumption to 15%/0%/2% from 10%/2%/2% previously and our net store addition assumptions to 200/190/170 from 175 a year previously. “Our FY21-23 earnings forecasts are raised by 4%/8%/8% respectively. Key downside risks are a sharp weakening of the ringgit against the renminbi (yuan) and trade restrictions by China,” he added. ....
25 Apr 2021 In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant transcripts, stathmin-2, has been tied to disease pathology. Now, two preprints uploaded to bioRXiv on April 4 detail another UNC13A. Variants in this gene increase risk for ALS/FTD. Neurons lacking nuclear TDP-43 mis-splice UNC13A, make less of the protein. UNC13A risk variants incorporate cryptic exons. This only occurs in brain and spinal cord tissue harboring TDP-43 deposits. One paper was penned by researchers led by Pietro Fratta, University College London, and Michael Ward, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. The second is from the labs of Aaron Gitler, Stanford University, California, and Leonard Petrucelli, Mayo Clinic, Jacksonville, Florida. Both papers report that if TDP-43 binding to UNC13A falters, t ....