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The Skinny on Ultrathin DES: Meta-analysis Shows Some Long-term Advantages


May 19, 2021
Compared with second-generation DES, devices with ultrathin struts are associated with less TLF, driven by reductions in clinically driven TLR, a long-term meta-analysis of multiple RCTs suggests.
The thinner struts have been thought to offer advantages in terms of producing less inflammation, vessel injury, neointimal proliferation, and thrombus formation. The new meta-analysis builds on the findings of a prior meta-analysis showing that ultrathin-strut DES were associated with a lower risk of TLF (composite of cardiac death, MI, or clinically driven TLR) at 1 year compared with conventional second-generation thin-strut DES.
Several additional
large-scale RCTs that have been completed in recent years, with extended follow-up to a mean of 2.5 years, differentiate the newer meta-analysis, which was presented today by Yousif Ahmad, MD (Cedars-Sinai Medical Center, Los Angeles, CA), at the EuroPCR 2021 virtual meeting. It was also simultaneously publishe ....

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Milestone Pharmaceuticals Reports First Quarter 2021 Financial Results and Provides Clinical, Regulatory, and Corporate Update


Milestone Pharmaceuticals Reports First Quarter 2021 Financial Results and Provides Clinical, Regulatory, and Corporate Update
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MONTREAL and CHARLOTTE, N.C., May 17, 2021 /PRNewswire/ Milestone Pharmaceuticals Inc. (Nasdaq: MIST), a biopharmaceutical company focused on the development and commercialization of innovative cardiovascular medicines, today reported financial results for the first quarter ended March 31, 2021 and provided a clinical, regulatory, and corporate update.
We continue to work closely with our existing clinical trial sites, as well as add new sites, to address the impact that the COVID-19 pandemic has had on patient enrollment in the pivotal Phase 3 RAPID trial of etripamil in patients with PSVT. While we are encouraged by recent improvements in enrollment rates, we now expect to report topline data from the RAPID trial in the second half of 2022, said Joseph Oliveto, President ....

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