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Molecular analysis identifies key differences in lungs of cystic fibrosis patients


Nature Medicine
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell).
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis. ....

Brigitte Gomperts , Barry Stripp , Kathrin Plath , John Jed Mahoney , Gianni Carraro , Justin Langerman , National Cancer Institute , Cystic Fibrosis Foundation , Tumor Cell Biology Training Program , Sinai Board Of Governors Regenerative Medicine Institute , Parkerb Francis Foundation Fellowship , National Heart , Blood Institute , Edythe Broad Center , Stem Cell Research , Cystic Fibrosis Foundation Therapeutics Lab , Broad Stem Cell Research Center , National Institutes Of Health , David Geffen School Of Medicine , Wm Keck Foundation , Disease Research Program , Cystic Fibrosis Foundation Epithelial Stem Cell Consortium , Howard Hughes Medical Institute , Nature Medicine , Regenerative Medicine , Cystic Fibrosis Foundation Therapeutics ,

The Culture Of Manipulation: How Tobacco Profiteers Use Culture To Con Us


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SAN FRANCISCO, April 7, 2021 /PRNewswire/ This year 480,000 Americans will die from tobacco induced disease.  Though this number is still astronomical, public health has made steady progress each year in reducing the toll.  Sadly, over the last few years public health advocates have watched with horror as the flavored e-cigarette epidemic exploded and lured a new generation of teenagers into tobacco addiction. Cities, counties, and states have moved to enact legislation to restrict the sale of flavored nicotine products.  Despite the science being quite clear that flavored tobacco products entice and hook new smokers, menthol and hookah products are sometimes, quite inexplicably, given exemptions by some municipalities.  ....

United States , San Diego , San Jose State University , Arnab Mukherjea , Carol Mcgruder , Tracy Brown , Wael Al Delaimy , Steven Millner , Wael Al Delaimi , Phillip Gardiner , University Of California , Tobacco Related Disease Research Program , Professor Of Health Sciences Public Community , Institute For Public Health , African American Tobacco Control Leadership Council , California State University , Health Sciences , Department Of Health Sciences , Department Of African American , Health Academic Program , Friday April , Esteemed Cultural , Academic Scholar , Tobacco Control Advocates , Tobacco Industry Uses Culture , Middle Eastern ,