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TRK Inhibitor Proves Beneficial in Primary CNS Tumors

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The TRK inhibitor larotrectinib (Vitrakvi) showed activity in patients with TRK fusion-positive primary central nervous system (CNS) tumors, according to an analysis of two trials.
Among 33 patients with primary CNS tumors, the median overall survival (OS) had not been reached over 16.5 months of follow-up, and the 1-year OS rate was 85%, reported Sébastien Perreault, MD, of CHU Sainte-Justine University Hospital in Montreal.
The median progression-free survival (PFS) was 18.3 months, and the 1-year PFS rate was 56%.
Larotrectinib is active in this population with a high unmet need for tolerable targeted therapeutic options, Perreault said during a presentation at the virtual American Society of Clinical Oncology (ASCO) annual meeting. ....

United States , University Hospital , Fort Pierce , Ed Susman , Jaishri Blakeley , Johns Hopkins University In Baltimore , American Society Of Clinical Oncology , Sainte Justine University Hospital , Justine University Hospital , American Society , Clinical Oncology , Johns Hopkins University , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் மருத்துவமனை , கோட்டை துளை , எட் சுஸ்மான் , ஜெய்ஷ்ரி பிளேக்லி , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் இல் பால்டிமோர் , அமெரிக்கன் சமூகம் ஆஃப் மருத்துவ புற்றுநோயியல் , புனிதர் ஜஸ்டின் பல்கலைக்கழகம் மருத்துவமனை , அமெரிக்கன் சமூகம் , மருத்துவ புற்றுநோயியல் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் ,

Kate Middleton has 2 tricks that help her stand in heels for hours - and you've probably never noticed them before

Kate Middleton has 2 tricks that help her stand in heels for hours - and you ve probably never noticed them before
INSIDER
4 hrs ago
lyang@insider.com (Lucy Yang,Amanda Krause)
© Chris Jackson/Getty Images
The Duchess of Cambridge is said to have numerous style secrets. Chris Jackson/Getty Images
Kate Middleton is said to use several tricks for staying comfortable in heels for hours.
According to royal etiquette expert Myka Meier, Middleton uses non-slip John Lewis tights.
The Duchess of Cambridge is also said to use Alice Bow insoles to cushion her feet.
Kate Middleton has two style secrets that help her wear heels for extended periods of time. ....

United Kingdom , Chris Jackson Getty , Rachel Bowditch , Tabitha Simmons , John Lewis , Myka Meier , Kate Middleton , John Lewi , Katie Nicholl , Sainte Justine University Hospital , Montreal Sainte Justine University Hospital On , Getty Images The Duchess , Getty Images , Alice Bow , Beaumont Etiquette , Footwear News , Getty Images Kate Middleton , Vanity Fair , Luxury Insoles , Victoria Arbiter , Queen Elizabeth , Commonwealth Games , Getty Images Middleton , ஒன்றுபட்டது கிஂக்டம் , கிறிஸ் ஜாக்சன் கெட்டி , ரேச்சல் போடிட்ச் ,

Why a Gatineau care home might be experiencing a 2nd COVID-19 outbreak

Posted: Mar 10, 2021 4:00 AM ET | Last Updated: March 10
CHSLD Lionel-Émond near the Hull Hospital in Gatineau, Que., is the site of a COVID-19 outbreak with 43 residents and 18 staff members infected. Five people have died.(Hugo Belanger/Radio-Canada)
Health experts are closely watching an outbreak at a long-term care home in Gatineau, Que., where residents and some staff have already been vaccinated.
This week, a team of health workers and infectious disease specialists were deployed as reinforcements to CHSLD Lionel-Émond.
The home is the site of an outbreak, with 43 residents and 18 staff members infected as of Tuesday. Five people have died. ....

Peter Juni , Zainab Abdurrahman , Mcmaster University , While Canada National Advisory Committee On Immunization , Sainte Justine University Hospital , Social Services , Christian Dub , Advisory Table , National Advisory Committee , பீட்டர் ஜூனி , ஜைநப் அப்துர்ரஹ்மான் , மக்மாஸ்டர் பல்கலைக்கழகம் , புனிதர் ஜஸ்டின் பல்கலைக்கழகம் மருத்துவமனை , சமூக சேவைகள் , கிறிஸ்துவர் டப் ,