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A Break from Chemo: PARP Inhibitor Shrinks Tumors in Pancreatic Cancer Patients with Mutations


Kim Reiss, MD
PHILADELPHIA More than two-thirds of pancreatic cancer patients harboring genetic mutations saw their tumor stop growing or shrink substantially after being switched from intensive chemotherapy to the PARP inhibitor rucaparib as a maintenance therapy, researchers from the Abramson Cancer Center at the University of Pennsylvania reported online today in the Journal of Clinical Oncology. The results from the phase II trial at the ACC support the use rucaparib for pancreatic cancer patients with BRCA1, BRCA2, and PALB2 variants to help control tumor growth without the aggressive side effects of chemotherapy.
Rucaparib a targeted therapy in pill form is currently approved by the U.S. Food and Drug Administration as a maintenance therapy for patients with recurrent ovarian and fallopian tube cancer and prostate cancer, but not pancreatic cancer. ....

University Of Pennsylvania , United States , Roberth Vonderheide , Markh Ohara , Lydia Henson , Thomas Karasic , Natallia Izgur , Charles Schneider , Rosemarie Mick , Katharine Nathanson , Zainm Hannan , Janae Romeo , Stacy Cowden , Gregory Beatty , Arnold Simon , Ursina Teitelbaum , Maxm Wattenberg , Kim Reiss , Susan Domchek , Traci Southwell , Rashmi Tondon , Drug Administration , Basser Center , Abramson Cancer Center , American Association For Cancer Research , Konner Fund ,

Penn-developed CAR T therapy shows long-lasting remissions in non-hodgkin lymphoma


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PHILADELPHIA A significant number of non-Hodgkin lymphoma (NHL) patients in a Penn Medicine-initiated clinical trial continue to be in remission five years after receiving the chimeric antigen receptor (CAR) T cell therapy Kymriah™, researchers in Penn s Abramson Cancer Center reported today in the
New England Journal of Medicine. The findings represent the longest follow-up, published data to date for CAR T cell therapies approved by the U.S. Food and Drug Administration for the treatment of relapsed or refractory large B-cell lymphomas.
Among 24 patients with diffuse large B-cell lymphoma (DLBCL), the most common form of NHL, who received the therapy after their cancers had come back following standard treatments, 46 percent achieved complete remission and 31 percent achieved progression-free survival at five years. Among 14 patients with relapsed or refractory follicular lymphoma, the second most common form of the disease, 71 percent achieved complete r ....

University Of Pennsylvania , United States , Stephenj Schuster , Marco Ruella , Elisea Chong , Penn Abramson Cancer Center , Lymphoma Program , Drug Administration , Perelman School Of Medicine , Abramson Cancer Center , Research In Penn Perelman School Of Medicine , Oncology In Penn Perelman School Of Medicine , Penn Medicine Initiated , New England Journal , Perelman School , Margarita Louis Dreyfus Professor , Chronic Lymphocytic Leukemia , Lymphoma Clinical Care , Medicine Health , Clinical Trials , Immunology Allergies Asthma , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , லிம்போமா ப்ரோக்ர்யாம் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , ஆராய்ச்சி இல் பென் பெரல்மேன் பள்ளி ஆஃப் மருந்து ,

Clinical trial shows five-year outcomes of CAR T-cell therapy for non-Hodgkin lymphomas

Clinical trial shows five-year outcomes of CAR T-cell therapy for non-Hodgkin lymphomas
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Stephenj Schuster , Marco Ruella , Elisea Chong , Emily Henderson , Penn Abramson Cancer Center , Lymphoma Program , Drug Administration , Perelman School Of Medicine , Abramson Cancer Center , Research In Penn Perelman School Of Medicine , Oncology In Penn Perelman School Of Medicine , Penn Medicine Initiated , New England Journal , Perelman School , Margarita Louis Dreyfus Professor , Chronic Lymphocytic Leukemia , Lymphoma Clinical Care , எமிலி ஹென்டர்சன் , லிம்போமா ப்ரோக்ர்யாம் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , ஆராய்ச்சி இல் பென் பெரல்மேன் பள்ளி ஆஃப் மருந்து , புற்றுநோயியல் இல் பென் பெரல்மேன் பள்ளி ஆஃப் மருந்து , பென் மருந்து தொடங்கப்பட்டது , புதியது இங்கிலாந்து இதழ் , பெரல்மேன் பள்ளி , மார்கரிட்டா லூயிஸ் ட்ரேஃபஸ் ப்ரொஃபெஸர் ,