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Researchers Uncover How MN1 Overexpression Causes AML


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Researchers Uncover How MN1 Overexpression Causes AML
Meningioma-1 (MN1) is a protein whose overexpression has been linked to acute myeloid leukemia (AML) and brain tumors, and 70% to 80% of AML patients with high overexpression of MN1 die within two years. Yet the mechanism by which MN1 causes these diseases has largely remained a mystery.
“Looking at the sequence, the protein has no obvious structure,” said Kathrin M. Bernt, MD, a pediatric oncologist in the Cancer Center’sLeukemia and Lymphoma Program at Children’s Hospital of Philadelphia (CHOP). “MN1 doesn’t resemble other typical oncogenes – or any other proteins – so it’s difficult to ascertain its function.” ....

United States , Kathrinm Bernt , Children Cancer Research Fund , Lymphoma Program At Children Hospital Of Philadelphia , Cancer Center Leukemia , Lymphoma Program , Kids Cancer , Cancer Research , ஒன்றுபட்டது மாநிலங்களில் , குழந்தைகள் புற்றுநோய் ஆராய்ச்சி நிதி , லிம்போமா ப்ரோக்ர்யாம் , கீட்ஸ் புற்றுநோய் , புற்றுநோய் ஆராய்ச்சி ,

Less is More for Next Generation of CAR T Cells


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Less is More for Next Generation of CAR T Cells
PHILADELPHIA When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn’t respond, they went back to the drawing board to determine why. They discovered that less is more when it comes to the length of what is known as the single-chain variable fragment the linker that bridges the two halves of the receptor that allows CAR T cells to latch onto tumor cells and attack them. ....

University Of Pennsylvania , United States , Nathan Singh , Saari Gill , Marco Ruella , Emily Whitehead Foundation , National Cancer Institute , Lymphoma Program , Novartis Alliance , Perelman School Of Medicine , Society Of Immunotherapy , Japan Agency For Medical Research , American Society Of Hematology Scholar Award , Novartis Penn Alliance , National Institutes Of Health , Drug Administration , V Foundation , Cancer Innovative Research Grant , Immunotherapy Frontier Program , Penn Medicine , Perelman School , Washington University School , Frontier Program , Curing Kids , National Institutes , Japan Agency ,