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Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication

Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication
In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C., when the conversation shifted to what was then a worrying viral epidemic in China. Without foreseeing the global disaster to come, they wondered aloud how they might contribute.
Nearly a year and a half later, those three scientists and their many collaborators across three national laboratories have published a comprehensive study in Biophysical Journal that - alongside other recent, complementary studies of coronavirus proteins and genetics - represents the first step toward developing treatments for that viral infection, now seared into the global consciousness as COVID-19. ....

United States , Oak Ridge , Greg Hura , Andrzej Joachimiak , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Protein Data Bank , Berkeley Lab Advanced Light Source , Argonne National Laboratory , Structural Biology Department , Bioimaging Division , Berkeley Lab Molecular Biophysics , Biophysical Journal , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Molecular Biophysics , Integrated Bioimaging , Oak Ridge National Laboratory , Advanced Light Source , Advanced Photon Source , High Flux Isotope Reactor , Spallation Neutron Source , Science National Virtual Biotechnology Laboratory , Added Joachimiak , ஒன்றுபட்டது மாநிலங்களில் ,

Deconstructing the infectious machinery of SARS-CoV-2

Deconstructing the infectious machinery of SARS-CoV-2
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Oak Ridge , Greg Hura , Andrzej Joachimiak , Lawrence Berkeley National Laboratory Lab , Protein Data Bank , Berkeley Lab Advanced Light Source , Argonne National Laboratory , Structural Biology Department , Bioimaging Division , Berkeley Lab Molecular Biophysics , Biophysical Journal , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Molecular Biophysics , Integrated Bioimaging , Oak Ridge National Laboratory , Advanced Light Source , Advanced Photon Source , High Flux Isotope Reactor , Spallation Neutron Source , Science National Virtual Biotechnology Laboratory , Added Joachimiak , ஒன்றுபட்டது மாநிலங்களில் , ஓக் ரிட்ஜ் ,

Deconstructing the Infectious Machinery of the SARS-CoV-2 Virus

Deconstructing the Infectious Machinery of the SARS-CoV-2 Virus
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United States , Oak Ridge , Department Of Energy , District Of Columbia , Greg Hura , Andrzej Joachimiak , University Of California , Office Of Science , Greg Hura Berkeley Lab , Argonne National Laboratory , Thor Swift Berkeley Lab , Berkeley Lab Molecular Biophysics , Structural Biology Department , National Institutes Of Health , Berkeley Lab Advanced Light Source , Lawrence Berkeley National Laboratory , Bioimaging Division , Lawrence Berkeley National Laboratory Lab , Research Facility , Protein Data Bank , Berkeley Lab , Biophysical Journal , Structural Biology , Molecular Biophysics , Integrated Bioimaging , Oak Ridge National Laboratory ,

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Biologists reveal unusual structure of coronavirus protein linked to immune evasion
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells. The structural map – which is now published in the journal PNAS, but has been open-access for the scientific community since August – has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body.
Using X-ray crystallography, we built an atomic model of ORF8, and it highlighted two unique regions: one that is only present in SARS-CoV-2 and its immediate bat ancestor, and one that is absent from any other coronavirus. These regions stabilize the protein – which is a secreted protein, not bound to the membrane like the viru ....

United States , Marc Allaire , James Hurley , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Bioimaging Division , Berkeley Lab Molecular Biophysics , Lead Author , Former Faculty Scientist , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Corona Virus , Amino Acid , Sars Cov 2 , X Ray , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , எமிலி ஹென்டர்சன் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.
The structural map - which is now published in the journal
PNAS, but has been open-access for the scientific community since August - has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body. ....

United States , Marc Allaire , James Hurley , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Bioimaging Division , Berkeley Lab Molecular Biophysics , Lead Author , Former Faculty Scientist , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Corona Virus , Amino Acid , Sars Cov 2 , X Ray , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , எமிலி ஹென்டர்சன் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,