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DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins

DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

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Drop the stress

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Under stress conditions, cells switch quickly from the normal to the crisis mode to prevent themselves from being damaged. This so-called heat shock response is associated with a rapid downregulation of gene activity to release capacities to cope with the threat. Researchers at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now discovered how exactly a stress-induced molecular droplet formation of the transcription regulator NELF downregulates transcription to promote cell survival upon stress.
All life on earth evolved multiple layers and networks of ensuring survival upon catastrophic events. Even cells have their emergency plan: the heat shock response. Triggered by multiple stress stimuli such as heat, toxins, or radiation, this cellular safety program tries to prevent permanent damage to the organism. The response resembles an overall adopted lockdown strategy witnessed during the global corona virus pandemic. During a lockdown, ....

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Wissenschaftspreis für Göttinger Chemiker Patrick Cramer

Wissenschaftspreis für Göttinger Chemiker Patrick Cramer
goettinger-tageblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from goettinger-tageblatt.de Daily Mail and Mail on Sunday newspapers.

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Coronavirus antibody therapies explained | Germany| News and in-depth reporting from Berlin and beyond | DW

Why are antibodies such an interesting research subject for epidemiologists during this pandemic?
How do bamlanivimab and REGN-CoV-2 work?
Both antibody treatments are designed to block the SARS-CoV-2 spike protein and thus prevent the virus from attaching to and entering human cells. These identical so-called monoclonal antibodies are lab-engineered and designed to attack one specific virus in one distinct way.
Bamlanivimab contains one monoclonal antibody. REGN-CoV-2, in contrast, consists of two monoclonal antibodies. US pharma company Regeneron says its antibody cocktail lowers the viral load, which helps symptoms dissipate more quickly.
The advantage of Regeneron s drug cocktail is that by containing two antibodies, it increases the chance that at least one of them will prove effective during treatment, virologist Sandra Ciesek told German public broadcaster NDR. ....

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Patrick Cramer receives the 2021 Louis-Jeantet Prize for Medicine

Credit: Irene Böttcher-Gajewski / Max Planck Institute for Biophysical Chemistry
The award is one of the most prestigious in Europe and endowed with 500,000 Swiss francs. With this prize the Louis-Jeantet Foundation honors the director at the Max Planck Institute (MPI) for Biophysical Chemistry for his pioneering work in the field of gene transcription. Transcription is a copying process enabling living cells to produce transcripts of their genes that then serve as blueprints for making proteins. Cramer s research focuses on the molecular machines, called RNA polymerases, that control this fundamental process of life.
Patrick Cramer has visualized the structures of many of these cellular copying machines in atomic detail for the first time. He demonstrated how RNA polymerases translate genetic information and how they work as a team with other protein complexes. His ground-breaking research provides deep insights into gene transcription with unprecedented detail. It is h ....

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