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Comprehensive genetic study provides new insights on cleft lip and palate


Comprehensive genetic study provides new insights on cleft lip and palate
Cleft lip and palate is one of the most common congenital malformations. Its causes are mainly genetic. However, it is still largely unknown exactly which genes are affected. A new international study led by the University of Bonn now provides new insights. The results are published in the journal
Human Genetics and Genomics Advances, but are already available online.
The researchers from the Institute of Human Genetics at the University Hospital Bonn combined various data sources in their work. In the course of their research, they discovered five new regions in the human genome in which variations in the DNA sequence are associated with an increased risk of malformation. A total of 45 such risk regions are now known. For some of them, the researchers were also able to show which genes are affected by these changes. Our results provide new insights into the development of the disease, but also ....

Nordrhein Westfalen , United States , Julia Welzenbach , Kerstin Ludwig , Emmy Noether , Emily Henderson , Bonn University Hospital , Johns Hopkins University In Baltimore , Institute Of Human Genetics , University Hospital Bonn , University Of Cantabria , Emory University In Atlanta , German Research Foundation , University Of Bonn , Human Genetics , Genomics Advances , Johns Hopkins University , Emory University , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பொன் பல்கலைக்கழகம் மருத்துவமனை , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் இல் பால்டிமோர் , நிறுவனம் ஆஃப் மனிதன் ஜெநெடிக்ஸ் , பல்கலைக்கழகம் மருத்துவமனை பொன் , பல்கலைக்கழகம் ஆஃப் கான்டாப்ரியா ,