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Princeton team discovers new organelle involved in cancer metastasis

Princeton cancer researchers Mark Esposito and Yibin Kang discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation when liquid blobs of living materials merge into each other. “We believe this is the first time that phase separation has been implicated in cancer metastasis,” said Kang. ....

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A new view of biology - ScienceBlog.com

A new view of biology
January 26, 2021Princeton
Cliff Brangwynne was seeing cells in the sidewalk again.
It was another long day in the lab at Harvard Medical School, where Brangwynne would often work late nights, staring at cells. Sometimes he spent so much time staring at cells through the microscope that the cells would follow him home, their shapes imprinted on his vision. Walking late at night, he’d see them dancing over the buildings and the empty streets and sidewalks.
Though Brangwynne was in his college years, he wasn’t a student in fact, some would call him a dropout. He’d been enrolled at Carnegie Mellon University, a ﬁrst-generation college student, when a mixture of burnout and wanderlust prompted him to take a year off midway through his degree. At ﬁrst he thought he would take a yearlong trip to Latin America. But he was interested in materials science he liked how it described the world in terms of math and physics. He also loved bi ....

United States , Mikko Haataja , Athanassios Panagiotopoulos , Cliff Brangwynne , Junek Wu , Carnegie Mellon , Tony Hyman , Andrej Ko , Mike Levine , Thomas Gregor , David Weitz , William Jacobs , Anthonyb Evnin , Donald Ingber , Ned Wingreen , Max Planck Institute Of Molecular Cell Biology , Princeton Center , Carnegie Mellon University , Harvard Medical School , Lewis Sigler Institute For Integrative Genomics , Blavatnik National Awards For Young Scientists , Princeton Bioengineering Initiative , School Of Engineering , Life Sciences , Catherinet Macarthur Foundation , Department Of Chemical ,

Cliff Brangwynne upends tradition to establish a new view of biology

Cliff Brangwynne upends tradition to establish a new view of biology
Jerimiah Oetting, for the Office of the Dean for Research
Jan. 25, 2021 9 a.m.
Clifford Brangwynne, the June K. Wu ’92 Professor of Chemical and Biological Engineering and inaugural director of the Princeton Bioengineering Initiative, sees similarities between living cells and salad dressing, in which oil and vinegar separate according to the laws of physics. The idea has caught on, and now many scientists are exploring how such physical processes can drive the formation of the cell’s structures and play key roles in cellular division and gene expression.
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