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Strong and balanced T cell response: key to controlling SARS-CoV-2 infection without getting COVID-19

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To effectively fight off SARS-CoV-2, the immune system depends on both antibodies and T cells, a type of white blood cell, which work together to eradicate the virus. However, little was known about virus-specific T cells in asymptomatic patients.
We now know that many people are getting infected with SARS-CoV-2 without realising it, as they stay healthy and don t develop any symptoms. These asymptomatic infections may provide the key to understanding how the immune system can control the virus without triggering pathological processes, explained Dr Nina Le Bert, Senior Research Fellow at the Duke-NUS Emerging Infectious Diseases (EID) Programme and the co-author of this study. ....

National University Hospital , Singapore General , Nina Le Bert , Patrick Casey , Clarencec Tam , Antonio Bertoletti , Senior Research , Dean For Research At , National Centre For Infectious Diseases , Swee Hock School Of Public Health , Senior Research Fellow , Emerging Infectious Diseases , Assistant Professor Clarence , Swee Hock School , Public Health , Singapore General Hospital , National Centre , Professor Antonio Bertoletti , Professor Patrick Casey , Senior Vice Dean , Medicine Health , Infectious Emerging Diseases , தேசிய பல்கலைக்கழகம் மருத்துவமனை , சிங்கப்பூர் ஜநரல் , நினா லெ பெர்ட் , பேட்ரிக் வழக்கு ,

Study finds SARS CoV-2-related viruses in Southeast Asian animals

Study finds SARS CoV-2-related viruses in Southeast Asian animals
Only 19 mammal species are longer-lived than humans relative to body size. Eighteen of them are bats, some living more than four decades. Photo: ReutersPremium
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While various researches are ongoing to investigate the origin and transmission of SARS-CoV-2 in China, a new study has warned that SARS-CoV-2-related coronaviruses (SC2r-CoVs) are circulating in animals such as bats and pangolins as far away as Thailand and are likely in other parts of Southeast Asia.
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Alaknanda River , India General , United Arab Emirates , United States , Japan General , Tamil Nadu , Wang Linfa , Supaporn Wacharapluesadee , Patrick Casey , Mohammed Bin Rashid Space Centre , Nature Communications , Senior Vice Dean For Research At , Chulalongkorn University , Hope Probe , Rashid Space Centre , Tanegashima Island , United Arab Emirates July , Prime Minister Narendra Modi , Southeast Asia , Nipah Virus , Southeast Asian , Emerging Infectious Diseases , Professor Wang Linfa , Emergency Use Authorisation , Professor Patrick Casey , Senior Vice Dean ,

Early induction of functional SARS-CoV-2-specific T cells linked with mild symptoms in COVID-19 patients

Early induction of functional SARS-CoV-2-specific T cells linked with mild symptoms in COVID-19 patients
Humoral and cellular adaptive immunity are two immune mechanisms that act against pathogens. Humoral immunity is mediated by antibodies, while cellular immunity does not involve antibodies and is, instead, facilitated by T cells. Studying how these immune mechanisms mediate SARS-CoV-2 infections could be beneficial in controlling the progression of the disease. However, their roles in viral control or disease pathogenesis is not fully understood and only a few studies have thoroughly monitored COVID-19 patients longitudinally, especially during the acute phase of infection.
To fill this knowledge gap, the team of researchers at Duke-NUS investigated the changes in virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from onset of the disease to recovery or death. ....

Patrick Casey , Martin Linster , Antonio Bertoletti , Emily Henderson , Senior Research , Dean For Research At , Study Co , Anthony Tanoto Tan , Senior Research Fellow , Emerging Infectious Diseases , Professor Antonio Bertoletti , Professor Patrick Casey , Senior Vice Dean , Sars Cov 2 , Immune Response , பேட்ரிக் வழக்கு , எமிலி ஹென்டர்சன் , மூத்தவர் ஆராய்ச்சி , டீன் க்கு ஆராய்ச்சி இல் , படிப்பு இணை , மூத்தவர் ஆராய்ச்சி சக , வளர்ந்து வருகிறது தொற்று நோய்கள் , ப்ரொஃபெஸர் பேட்ரிக் வழக்கு , மூத்தவர் துணை டீன் , நோய் எதிர்ப்பு சக்தி பதில் ,

Early functional SARS-COV-2 specific T cell response may prevent severe infection

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Humoral and cellular adaptive immunity are two immune mechanisms that act against pathogens. Humoral immunity is mediated by antibodies, while cellular immunity does not involve antibodies and is, instead, facilitated by T cells. Studying how these immune mechanisms mediate SARS-CoV-2 infections could be beneficial in controlling the progression of the disease. However, their roles in viral control or disease pathogenesis is not fully understood and only a few studies have thoroughly monitored COVID-19 patients longitudinally, especially during the acute phase of infection.
To fill this knowledge gap, the team of researchers at Duke-NUS investigated the changes in virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from onset of the disease to recovery or death. ....

Patrick Casey , Martin Linster , Antonio Bertoletti , Senior Research , Dean For Research At , Senior Research Fellow , Emerging Infectious Diseases , Professor Antonio Bertoletti , Professor Patrick Casey , Senior Vice Dean , பேட்ரிக் வழக்கு , மூத்தவர் ஆராய்ச்சி , டீன் க்கு ஆராய்ச்சி இல் , மூத்தவர் ஆராய்ச்சி சக , வளர்ந்து வருகிறது தொற்று நோய்கள் , ப்ரொஃபெஸர் பேட்ரிக் வழக்கு , மூத்தவர் துணை டீன் ,

Singapore designs 'armoured' anti-cancer T cells against immunosuppressants

Singapore designs armoured anti-cancer T cells against immunosuppressants
19 January 2021 | News
New ‘armoured’ T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection.
Photo Credit: Freepik
Duke-NUS Medical School researchers, together with collaborators in Singapore, have designed armoured immune cells that can attack recurring cancer in liver transplant patients, while temporarily evading immunosuppressant drugs patients take to avoid organ rejection. The findings were published in the journal
Hepatology.
Hepatocellular carcinoma is the most common type of primary liver cancer and the sixth most common cancer worldwide. It often develops in people with chronic liver disease following hepatitis B infection. ....

Patrick Casey , Antonio Bertoletti , Dean For Research , Infectious Diseases Programme , Professor Antonio Bertoletti , Emerging Infectious Diseases , Prof Bertoletti , Professor Patrick Casey , Senior Vice Dean , Anti Cancert Cells Against Immunosuppressants , பேட்ரிக் வழக்கு , டீன் க்கு ஆராய்ச்சி , தொற்று நோய்கள் ப்ரோக்ராம் , வளர்ந்து வருகிறது தொற்று நோய்கள் , ப்ரொஃபெஸர் பேட்ரிக் வழக்கு , மூத்தவர் துணை டீன் ,