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New nature communications publication by mann & theis groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics


New Nature Communications publication by Mann & Theis Groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics
Bruker Corporation today announces a seminal publication from the groups of Professors Matthias Mann and Fabian Theis in the journal Nature Communications with the title ‘Deep learning the collisional cross sections of the peptide universe from a million experimental values’ by Florian Meier et al. (doi.org/10.1038/s41467-021-21352-8).
Figure 1. Large-scale peptide collisional cross section (CCS) measurement with TIMS and PASEF. From Deep learning the collisional cross sections of the peptide universe from a million experimental values . (a) Workflow from extraction of whole-cell proteomes through digestion, fractionation, and chromatographic separation of each fraction. The TIMS-quadrupole TOF mass spectrometer was operated in PASEF mode. (b) Overview of the CCS dataset in this stud ....

Matthias Mann , Bruker Daltonicsmar , Gary Kruppa , Florian Meier , Fabian Theis , Nature Communications , University Of Copenhagen , Jena University Hospital , German Research Center , Max Planck Institute Of Biochemistry , Environmental Health , Novo Nordisk Foundation Center , Protein Research , Helmholtz Center Munich , Department Of Mathematics , Bruker Corporation , From Bruker Daltonicsmar , Professors Matthias Mann , Source Data , Professor Matthias Mann , Max Planck Institute , Professor Fabian Theis , Assistant Professor , Functional Proteomics , Pan Human , Bruker Vice President ,

New technology helps study muscle biology more clearly


New technology helps study muscle biology more clearly
Exercising regularly is one of the best defenses against metabolic diseases, such as obesity and diabetes - but why? It s a question that scientists are still struggling to answer. While exercising changes the molecular behavior of muscles, it s not well understood how these molecular changes improve metabolic health.
Scientists at the University of Copenhagen have now developed a new technology that allows researchers to study muscle biology on a more detailed level - and hopefully find some new answers. They extracted fast and slow twitch muscle fibers from freeze-dried muscle samples that were taken before and after 12 weeks of cycling exercise training. Their comprehensive analysis of the protein expression of the fibers provides new evidence that the fiber types respond differently to exercise training. ....

Matthias Mann , Emily Henderson , Protein Research , Nature Communications , University Of Copenhagen , Wojtaszewski Group , Department Of Nutrition , Metabolic Research , Novo Nordisk Foundation Center , Associate Professor , Basic Metabolic Research , Atul Deshmukh , Professor Matthias Mann , Associate Professor Atul Deshmukh , Protein Expression , மத்தியாஸ் மான் , எமிலி ஹென்டர்சன் , ப்ரோடீந் ஆராய்ச்சி , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , துறை ஆஃப் ஊட்டச்சத்து , வளர்சிதை மாற்ற ஆராய்ச்சி , இணை ப்ரொஃபெஸர் , அடிப்படை வளர்சிதை மாற்ற ஆராய்ச்சி , ஆதுள் தேஷ்முக்ஹ் , ப்ரொஃபெஸர் மத்தியாஸ் மான் ,

New technology reveals fast and slow twitch muscle fibers respond differently to exercise


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Exercising regularly is one of the best defences against metabolic diseases, such as obesity and diabetes - but why? It s a question that scientists are still struggling to answer. While exercising changes the molecular behaviour of muscles, it s not well understood how these molecular changes improve metabolic health.
Scientists at the University of Copenhagen have now developed a new technology that allows researchers to study muscle biology on a more detailed level - and hopefully find some new answers. They extracted fast and slow twitch muscle fibers from freeze-dried muscle samples that were taken before and after 12 weeks of cycling exercise training. Their comprehensive analysis of the protein expression of the fibers provides new evidence that the fiber types respond differently to exercise training. ....

Matthias Mann , Protein Research , Nature Communications , University Of Copenhagen , Wojtaszewski Group , Department Of Nutrition , Metabolic Research , Novo Nordisk Foundation Center , Associate Professor Atul Deshmukh , Basic Metabolic Research , Atul Deshmukh , Professor Matthias Mann , Cell Biology , Medicine Health , Diet Body Weight , Orthopedic Medicine , Sports Medicine , Sports Recreation , மத்தியாஸ் மான் , ப்ரோடீந் ஆராய்ச்சி , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , துறை ஆஃப் ஊட்டச்சத்து , வளர்சிதை மாற்ற ஆராய்ச்சி , இணை ப்ரொஃபெஸர் ஆதுள் தேஷ்முக்ஹ் , அடிப்படை வளர்சிதை மாற்ற ஆராய்ச்சி ,

Bruker and Evosep Announce Major Progress in Unbiased, Quantitative True Single-cell Proteomics


Press release content from Business Wire. The AP news staff was not involved in its creation.
Bruker and Evosep Announce Major Progress in Unbiased, Quantitative True Single-cell Proteomics
January 5, 2021 GMT
Figure 1: Evosep One LC and timsTOF Pro MS (Photo: Business Wire)
BILLERICA, Mass. & ODENSE, Denmark (BUSINESS WIRE) Jan 5, 2021
Bruker Corporation (Nasdaq: BRKR) and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified
timsTOF Pro mass spectrometer connected to an
Evosep One low-flow chromatography system.
Figure 1: Evosep One LC and timsTOF Pro MS (Photo: Business Wire)
These advances have been demonstrated by the Mann-group in a paper by ....

United States , Miroslava Minkova , Matthias Mann , Christian Ravnsborg , Nicolai Bache , Gary Kruppa , Petra Scheffer , Bruker Daltonics Marketing Communications , Investor Relations Corporate Development , Bruker Corporation , Bruker Corporation Nasdaq , Max Planck Institute Of Biochemistry , Evosep One , Business Wire , Professor Matthias Mann , Max Planck Institute , Vice President , Bruker Media Contact , Investor Contact , Investor Relations , Media Contact , Western Europe , ஒன்றுபட்டது மாநிலங்களில் , மத்தியாஸ் மான் , நிகோலாய் பச்செ , கேரி கிருப்பா ,