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Meet the scientist developing future antibiotics | East Anglian Daily Times


Professor Matt Hutchings is a group leader at the John Innes Centre
- Credit: Jake Newitt
Our medicines are becoming increasingly ineffective as pathogens that cause infectious diseases evolve. Professor Matt Hutchings, a group leader at the John Innes Centre (JIC), explains how his research team is working to discover new antibiotics that could be instrumental in the fight against antimicrobial resistance. 
‘Norwich is a great place to do science, a great place to live and it’s got a great football team!’ says Professor Matt Hutchings
- Credit: Matt Hutchings
Each month, those working at the pioneering heart of Norwich Research Park tell us how their work is shaping the world we live in. Read their stories here.  ....

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Gene-editing produces tenfold increase in superbug slaying antibiotics


Date Time
Gene-editing produces tenfold increase in superbug slaying antibiotics
Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics.
The John Innes Centre researchers used the technology to create a new strain of Streptomyces formicae bacteria which over-produces the medically promising molecules.
Discovered within the last ten years, formicamycins have great potential because, under laboratory conditions, superbugs like MRSA do not become resistant to them.
However, Streptomyces formicae only produce the antibiotics in small quantities. This has made it difficult to scale up purification for further study and is an obstacle to the molecules being taken forward for clinical trials. ....

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