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Researchers identify a genetic defect that increases the risk of debilitating eye disease


Researchers identify a genetic defect that increases the risk of debilitating eye disease
A genetic defect could hold the key to preventing or delaying the onset of a debilitating eye disease that can lead to vision loss and blindness.
MacTel (macular telangiectasia type 2) affects one in 1,000 Australians. Symptoms include slow loss of vision, distorted vision and trouble reading. Because early signs of the disorder are subtle, it is difficult to diagnose.
Researchers have identified an additional seven regions in the human genome that increase the risk of developing the condition, including a rare DNA mutation in the PHGDH gene, which will help clinicians to better diagnose and treat it. ....

United States , United Kingdom , Melanie Bahlo , Brendan Ansell , Roberto Bonelli , Emily Henderson , Lowy Medical Research Institute , Communications Biology , Eye Hospital , Professor Bahlo , Eye Disease , Amino Acid , Blood Vessels , Medical Research , Vision Loss , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பிரெண்டன் முன்செல்ல , ரொபெர்டோ போனெல்லி , எமிலி ஹென்டர்சன் , தாழ்வான மருத்துவ ஆராய்ச்சி நிறுவனம் , தகவல்தொடர்புகள் உயிரியல் , கண் மருத்துவமனை , கண் நோய் , அமினோ அமிலம் , இரத்தம் நாளங்கள் ,

WANdisco grants industry leading LiveData Platform to fast-track high-volume genome analysis and Covid-19 research in South Korea


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SAN RAMON, Calif., March 17, 2021 /PRNewswire/
WANdisco, the LiveData company, announced today that it donated its LiveData Platform to help Korea Research Institute of Bioscience & Biotechnology conduct faster analysis in its efforts towards Covid-19 research. Using the automated data migration and replication platform, the institute has been able to replicate files between Hadoop-based big data clusters and Linux-based analysis clusters 13 times faster than before, and reduce analysis time by over 30 percent.
In early 2020, WANdisco announced free access to their suite of cloud migration and big data tools for teams involved in research and developing potential treatments and cures for the Covid-19 pandemic. WANdisco provided its LiveData Platform along with technical resources to Korean Bioinformation Center (KOBIC) to assist the organization in enhancing its architecture, developing products, and introducing WANdisco s automated replication technology into ....

Josh Turner , David Richards , Silicon Valley Communications , Computational Development Team , Korean Bioinformation Center , Genomic Analysis Program Execution Cluster Lustre , Korea Bioinformation Center , Big Data Analysis Program Execution Cluster , Korea Research Institute Of Bioscience Biotechnology , Livedata Platform , Korea Research Institute , Hadoop Distributed File System , Clive Data , Co Vid , ஜோஷ் டர்னர் , டேவிட் ரிச்சர்ட்ஸ் , சிலிக்கான் பள்ளத்தாக்கு தகவல்தொடர்புகள் , கணக்கீட்டு வளர்ச்சி அணி , பெரியது தகவல்கள் பகுப்பாய்வு ப்ரோக்ர்யாம் மரணதண்டனை கொத்து , கொரியா ஆராய்ச்சி நிறுவனம் ஆஃப் உயிர் அறிவியல் உயிரி தொழில்நுட்பவியல் , கொரியா ஆராய்ச்சி நிறுவனம் , ஹடூப் விநியோகிக்கப்பட்டது கோப்பு அமைப்பு , வாழ தகவல்கள் , இணை வித் ,

New method for genome assembly in barley provides excellent results


New publication by iDiv member at IPK Leibniz Institute
Based on a press release by IPK Leibniz Institute
Gatersleben. Genomes differ between the individuals of one species and we can learn a lot about diversity in our crops by comparing genomes of different varieties. However, researchers that want to study many genomes need a fast and reliable method for sequence assembly. An international research team led by the IPK Leibniz Institute has now investigated a new DNA sequencing method. The results, which have now been published in the journal The Plant Cell, are very promising. The scientists now hope to be able to use the method for assembling other barley genomes in the future. ....

Sachsen Anhalt , Nils Stein , Uwe Scholz , Martin Mascher , Thomas Lux , Andrewg Sharpe , Jerry Jenkins , Jeremy Schmutz , Samuel Holden , Manuel Spannagl , Curtisj Pozniak , Klausfx Mayer , Christopher Plott , Chu Shin Koh , Inmaculada Hern , Jane Grimwood , Heidrun Gundlach , Zuzana Tulpov , Leibniz Institute , Group On Domestication Genomics , German Center , Integrative Biodiversity Research , Leibniz Institute In Gatersleben , Plant Cell , Independent Working Group , Domestication Genomics ,

Study finds significant variation in biomarker test utilization and treatment for non–small-cell lung cancer


Study finds significant variation in biomarker test utilization and treatment for non–small-cell lung cancer
Biomarker testing surveys specific disease-associated molecules to predict treatment response and disease progression; however its use has complicated the diagnosis of non-small-cell lung cancer (NSCLC). In a new study in
The
Journal of Molecular Diagnosis, published by Elsevier, investigators provide for the first time a complete overview of biomarker testing, spanning multiple treatment lines, in a single cohort of patients.
Using exploratory data analysis and process-mining techniques in a real-world setting, investigators identified significant variation in test utilization and treatment. They also found that while whole-genome sequencing, in which a patient s unique DNA is mapped at once, may not be a cost saving alternative to biomarker testing, as some have suggested, it may have other benefits for patients, such as decreasing the time between test ....

Maarten Ijzerman , Emily Henderson , University Of Twente , Services Research , Health Technology , University Of Melbourne Centre For Cancer Research , Techmed Center , Molecular Diagnosis , Professor Maarten , Melbourne Centre , Cancer Research , First Author , Phd Candidate , Lung Cancer , Molecular Diagnostics , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் இருபது , சேவைகள் ஆராய்ச்சி , ஆரோக்கியம் தொழில்நுட்பம் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் மையம் க்கு புற்றுநோய் ஆராய்ச்சி , தொழில்நுட்பம் மையம் , மூலக்கூறு நோயறிதல் , ப்ரொஃபெஸர் மார்டன் , மெல்போர்ன் மையம் , புற்றுநோய் ஆராய்ச்சி , முதல் நூலாசிரியர் ,

SARS-CoV-2 Brazilian variant may potentially escape T cell-mediated host immune responses

A team of scientists from Brazil recently explored the abilities of the UK, South African, and Brazilian variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to evade host CD8+ T cell responses induced by natural infection or vaccination. The findings reveal reduced antigenic coverage for the P.2 Brazilian lineage, indicating its ability to evade SARS-CoV-2-induced T cell responses. ....

South Africa , United Kingdom , South African , Sanchari Sinha Dutta , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,