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Nanotech Jumps Blood-Brain Barrier To Kill Cancer in Mice


Nanotech Jumps Blood-Brain Barrier To Kill Cancer in Mice
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research shows.
 
The study is the first to demonstrate an intravenous medication that can cross the blood-brain barrier.
I’ve worked in this field for more than 10 years and have not seen anything like this.
The discovery could one day allow new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults, and one whose incidence is rising in many countries. Today’s median survival for patients with glioblastoma is around 18 months; the average 5-year survival rate is below 5%. ....

United States , Maria Castro , Joerg Lahann , Nature Communications , Catalyst Awards Program , University Of Michigan Department , Marian Falk Medical Research , National Institutes Of Health , Chadtough Foundation , Biointerfaces Institute , University Of Michigan , Smiles For Sophie Forever Foundation , University Of Michigan Biointerfaces Institute , National Institute Of Neurological Disorders Stroke , Good Men Project , National Institutes , National Institute , Neurological Disorders , Marian Falk Medical Research Trust , Michigan Biointerfaces Institute , Happy Hearts , Sophie Forever , Creative Common , Premium Member , ஒன்றுபட்டது மாநிலங்களில் , மரியா காஸ்ட்ரோ ,

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease


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Atherosclerosis is marked by the buildup of inflammatory cells which narrow arteries to the point of chest pain and muscle weakness. Severe cases result in lesions and internal ruptures of arteries or even thrombosis in coronary arteries. One way that investigators are working to understand how atherosclerosis occurs and progresses is by looking at long non-coding RNAs (lncRNAs), strands of RNA that are not translated into proteins and which may play integral but understudied roles in cell regulation and disease progression. Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women s Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. Results are published in ....

United States , Mark Feinberg , Sarnoff Cardiovascular Research Foundation Fellowship , Arthurk Watson Charitable , Nature Communications , American Heart Association , Marian Falk Medical Research , National Institutes Of Health , Brigham Division Of Cardiovascular Medicine , Swiss National Science Foundation , Macrophage Associated Atherosclerosis , National Institutes , Charitable Trust , Marian Falk Medical Research Trust , ஒன்றுபட்டது மாநிலங்களில் , குறி ஃபைன்பெர்க் , சர்னொப்ப் இருதய ஆராய்ச்சி அடித்தளம் கூட்டுறவு , இயற்கை தகவல்தொடர்புகள் , அமெரிக்கன் இதயம் சங்கம் , மரியன் ஃபாக் மருத்துவ ஆராய்ச்சி , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ப்ரிகாம் பிரிவு ஆஃப் இருதய மருந்து , சுவிஸ் தேசிய அறிவியல் அடித்தளம் , தேசிய நிறுவனங்கள் , தொண்டு நம்பிக்கை , மரியன் ஃபாக் மருத்துவ ஆராய்ச்சி நம்பிக்கை ,

Collaboration Driving Progress: LLS Forms Alliances with Leading Cancer Institutions and Foundations to Co-Fund nearly $17 million in New Research Grants


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RYE BROOK, N.Y., Dec. 14, 2020 /PRNewswire/  As the world confronts a viral pandemic not seen in the past 100 years, the reverberations are being felt across every sector, from healthcare to the economy, education, business and science, including the blood cancer community. Blood cancers don t stop for the Covid-19 virus and the urgent need for collaboration to address these challenges has never been starker.
In response, The Leukemia & Lymphoma Society (LLS) today announced it has forged significant alliances with premier foundations, cancer institutions and philanthropic individuals, bringing their collective resources to bear to co-fund approximately $9 million in new research grants, with up to $8 million more funding anticipated over the next year. This cooperation will allow LLS to continue driving forward impactful research to find better treatments and cures for patients with leukemia, lymphoma, myeloma and other blood c ....

United States , South Australia , Harryt Mangurian Jr , Kimberly Stegmaier , Johanna Melo Cardenas , Jennifer Trowbridge , Frederick Locke , Sylvain Simon , Therese Vu , Stanford Universityanddaniel Thomas , Ravindra Majeti , Lee Greenberger , John Pimanda , Andrea Greif , Rising Tide Foundation For Clinical Cancer Research , National Cancer Institute , Foundation For Childhood Cancer Research , Marian Falk Medical Research , Md Anderson Cancer Center , Sarah Cannon Foundation , Mark Foundation , Dana Farber Cancer Institute , Fred Hutchinson Cancer Research Center , Australia Health , Children Initiative , National Institutes Of Health ,